doiSerbia

Recurrent aphthous stomatitis as the only clinical sign of celiac disease in obese adolescent - case report and literature review

Mandić Jelena (University of Belgrade, School of Dental Medicine, Clinic for Pediatric and Preventive Dentistry, Belgrade, Serbia)
Radlović Nedeljko (The Serbian Medical Society, Academy of Medical Sciences, Belgrade, Serbia), n.radlovic@beotel.net
Leković Zoran (University of Belgrade, Faculty of Medicine, Belgrade, Serbia + University Children’s Hospital, Belgrade, Serbia)
Radlović Vladimir (University of Belgrade, Faculty of Medicine, Belgrade, Serbia + University Children’s Hospital, Belgrade, Serbia)
Dučić Siniša (University of Belgrade, Faculty of Medicine, Belgrade, Serbia + University Children’s Hospital, Belgrade, Serbia)
Nikolić Dejan (University of Belgrade, Faculty of Medicine, Belgrade, Serbia + University Children’s Hospital, Belgrade, Serbia)
Jovičić Olivera (University of Belgrade, School of Dental Medicine, Clinic for Pediatric and Preventive Dentistry, Belgrade, Serbia)

Introduction. Recurrent aphthous stomatitis (RAS) is a relatively common oral mucosal lesion of unclear etiology. It occurs in otherwise healthy people, but also in various infectious and non-infectious diseases, including celiac disease (CD). We present an obese adolescent with RAS as the only clinical sign of CD. Case outline. An adolescent aged 15 2/12 years come with very pronounced RAS in previous five months. He had no other difficulties. The patient was obese from the age of 12. Other data were without peculiarities. On admission he was 165 cm tall (P25), obese (BMI 27 kg/m2), in the final stage of puberty, with stretch marks in the distal areas of the abdomen, thighs and gluteus and very pronounced pain-sensitive aphthae in the buccal and labial mucosa accompanied by swelling of the lips and perioral region. Except for lower serum iron levels (8 μmol/l), routine laboratory blood tests were within the reference range. The serological test for CD was positive (antibodies to tissue transglutaminase IgA 78.5 U/ml, anti-endomysial antibodies IgA positive). Endoscopy revealed reflux esophagitis, without any other pathological findings. Stereomicroscopic and pathohistological analysis of the duodenal mucosa samples showed mild destructive enteropathy (Marsh IIIa). Pathohistological examination of the gastric mucosa revealed grade I-II lymphocytic gastritis. The urease test for Helicobacter pylori was negative. A gluten-free diet resulted in the withdrawal of aphthous stomatitis and no recurrence later. Conclusion. Within the differential diagnostic analysis of the RAS causes, CD should also be considered. Additionally, obesity does not exclude the presence of CD.

Keywords: recurrent aphthous stomatitis, celiac disease, obesity