doiSerbia

Clinical efficacy of casein phosphopeptide - amorphous calcium phosphate and casein phosphopeptide-amorphous calcium fluoride phosphate and their influence on the quality of life in patients with Sjögren’s syndrome

Perić Tamara (University of Belgrade, School of Dental Medicine, Department of Pediatric and Preventive Dentistry, Belgrade, Serbia), tamara.peric@stomf.bg.ac.rs
Marković Dejan (University of Belgrade, School of Dental Medicine, Department of Pediatric and Preventive Dentistry, Belgrade, Serbia)
Tomić-Spirić Vesna (University of Belgrade, Faculty of Medicine, Clinic for Allergology and Immunology, Belgrade, Serbia;)
Petrović Bojan (University of Novi Sad, Faculty of Medicine, Dentistry Clinic of Vojvodina, Department of Pediatric and Preventive Dentistry, Novi Sad, Serbia)
Perić-Popadić Aleksandra (University of Belgrade, Faculty of Medicine, Clinic for Allergology and Immunology, Belgrade, Serbia;)
Marković Evgenija (University of Belgrade, School of Dental Medicine, Department of Orthodontics, Belgrade, Serbia)

Introduction/Objective. The purpose of this study was to compare clinical efficacy of casein phosphopeptide – amorphous calcium phosphate (CPP-ACP) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) with 0.05% NaF, and to assess their influence on the quality of life among individuals with Sjogren’s syndrome. Methods. Thirty patients were randomized into three groups treated with different remineralizing agents: CPP-ACP, CPP-ACFP, and 0.05% NaF. Oral health was evaluated at the beginning of the study, after 28 days (short-term effects), and after six months. The diagnosis of dental caries was performed using the decayed, missing, and filled teeth (DMFT) / decayed and filled surfaces (DFS) criteria. Enamel demineralization was visually examined using the white spot lesion index (Gorelick). The gingival health was evaluated with the gingival index (Loe–Silness). Assessment of oral hygiene was done using the simplified oral hygiene index (Greene–Vermilion). The Xerostomia Inventory was used to quantify dry-mouth symptoms. The oral health-related quality of life was analyzed using the short form of the Oral Health Impact Profile (OHIP-14). Results. During the evaluation period, caries increment was not significant. Considerable regression of white spot lesions was noted in all three experimental groups (p < 0.001). No significant improvement in gingival health and oral hygiene was observed. Physical pain was decreased in all three experimental groups, and subjective feeling of dry mouth was reduced in CPP-ACP and CPP-ACFP groups. Conclusion. CPP-ACP and CPP-ACFP may reduce the caries activity and relieve the dry-mouth symptoms in patients with Sjogren’s syndrome.

Keywords: caries, casein phosphopeptide-amorphous calcium phosphate, casein phosphopeptide-amorphous calcium fluoride phosphate, dry mouth, Sjögren’s syndrome