doiSerbia

Drug rash with eosinophilia and systemic symptoms syndrome in an adolescent - efficiency of immunoglobulin G in a corticosteroid resistant case

Stojković Anđelka (University of Kragujevac, Faculty of Medicine, Department of Pediatrics, Kragujevac, Serbia + Clinical Center of Kragujevac, Kragujevac, Serbia), andja410@mts.rs
Janković Slobodan (Clinical Center of Kragujevac, Kragujevac, Serbia + University of Kragujevac, Faculty of Medical Sciences, Department of Pharmacology, and toxicology, Kragujevac, Serbia)
Milovanović Dragan (Clinical Center of Kragujevac, Kragujevac, Serbia + University of Kragujevac, Faculty of Medical Sciences, Department of Pharmacology, and toxicology, Kragujevac, Serbia)
Đinđić Jasmina (Clinical Center of Kragujevac, Kragujevac, Serbia)
Veličković Vesna (Clinical Center of Kragujevac, Kragujevac, Serbia)

Introduction. Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome (sy) to carbamazepine has a heterogeneous clinical presentation. The aim of this report is to indicate the efficacy of immunoglobulin G in the treatment of corticosteroidresistant DRESS sy. Case outline. An adolescent suffering from epilepsy treated with carbamazepine and Na-valproate was hospitalized for fever, elevated transaminases, lymphadenopathy, splenomegaly. There was an eruption of skin efflorescence daily. On the sixth day of hospitalization, the number of eosinophils increased to 24% (780/ml absolute number). There was no desired response to methylprednisolone during the first eight days of treatment or to prednisolone during further treatment, with concomitant administration of antihistamines from day one of hospitalization, to Na-valproate, metformin hydrochloride, elimination diets, and carbamazepine withdrawal. Significant clinical, hematologic, and biochemical improvement occurred the day after the first dose of intravenous immunoglobulin G (IVIG). Conclusion. We point out the need to change the DRESS sy treatment recommendations in favor of the IVIG (as soon as the third or fourth day of treatment) in patients in whom the treatment with corticosteroids has no effect. Until new cases of the proven role of IVIG in the treatment of DRESS sy are published, corticosteroids remain the first therapeutic choice.

Keywords: Drug Hypersensitivity Syndrome, pediatrics, corticosteroids, immunoglobulin G