Srpski arhiv za celokupno lekarstvo 2018 Volume 146, Issue 3-4, Pages: 131-135
https://doi.org/10.2298/SARH170508131P
Full text ( 474 KB)
The influence of intravitreally applied triamcinolone acetonide on vitreal hemorrhage resorption and visual acuity in patients with proliferative diabetic retinopathy
Petrović Nenad (Department of Ophthalmology, Faculty of Medical Sciences, University of Kragujevac, Serbia + Clinical Centre Kragujevac, Clinic of Ophthalmology)
Todorović Dušan (Department of Ophthalmology, Faculty of Medical Sciences, University of Kragujevac, Serbia)
Srećković Sunčica (Department of Ophthalmology, Faculty of Medical Sciences, University of Kragujevac, Serbia + Clinical Centre Kragujevac, Clinic of Ophthalmology)
Šarenac-Vulović Tatjana (Department of Ophthalmology, Faculty of Medical Sciences, University of Kragujevac, Serbia + Clinical Centre Kragujevac, Clinic of Ophthalmology)
Janićijević-Petrović Mirjana (Department of Ophthalmology, Faculty of Medical Sciences, University of Kragujevac, Serbia + Clinical Centre Kragujevac, Clinic of Ophthalmology)
Paunović Svetlana (Clinic of Ophthalmology, Clinical Centre Kragujevac, Serbia)
Janićijević Katarina (Faculty of Medical Sciences, Department of Social medicine, Kragujevac)
Jovanović Svetlana (Department of Ophthalmology, Faculty of Medical Sciences, University of Kragujevac, Serbia + Clinical Centre Kragujevac, Clinic of Ophthalmology)
Introduction/Objective. Vitreal hemorrhage (VH) is one of the possible
complications of the diabetic retinopathy which is followed by intensive
decrease of visual acuity. Corticosteroides are commonly used in treatment
of different retinal diseases, due to their antiinflammatory and
anti-angiogenetic effect. Triamcinolone acetonide applied invtravitreally
remains in the eye for several months, releases its crystals and decreases
the density of vitreal hemorrhage. The aim of this study was to evaluate the
efficacy of 20 mg intravitreal triamcinolone acetonide for the managementof
long lasting VH, occurred as a complication of proliferative diabetic
retinopathy (PDR) in non-vitrectomized eyes. Methods. In prospective study,
from January 1st 2015 until the January 1st 2016, 24 patients with VH who
received intravitreal triamcinolone acetonide, were compared to 21 patients
from the control group (patients with PDR and similar degree of VH). All
patients passed ophthalmological examination at the beginning of the study,
7 days, 1, 3, 6, 9 and 12 months after intravitreal application of 20mg
triamcinolone acetonide. Besides VH and visual acuity, intraocular pressure
and cataract development were also analyzed. Results. Statistically
significant difference was recorded 1st and 3rd month after the usage of
triamacinolone, in the density of vitreal hemorrhage and visual acuity.
Twenty-nine percent of patients had temporally intraocular pressure rise
after the intravitreal triamacinolone application, and 4.1% of patients
ended the study with the developed cataract. Conclusion. Intravitreally
applied triamcinolone acetonide has moderate and temporary influence on the
velocity of vitreal hemorrhage reabsorption. It can be useful treatment
option when the vitrectomy in not possible.
Keywords: triamcinolone acetonide, vitrealhemorrhage, intravitreal injection, intraocularpressure