Srpski arhiv za celokupno lekarstvo 2018 Volume 146, Issue 3-4, Pages: 136-142
https://doi.org/10.2298/SARH170222144M
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Comparing characteristics of the optic nerve head among subjects with suspected glaucoma in different ages of onset
Marić Vesna (Clinical Center of Serbia, Clinic for Eye Diseases, Belgrade + School of Medicine, Belgrade)
Marković Vujica (Clinical Center of Serbia, Clinic for Eye Diseases, Belgrade + School of Medicine, Belgrade)
Božić Marija (Clinical Center of Serbia, Clinic for Eye Diseases, Belgrade + School of Medicine, Belgrade)
Marjanović Ivan (Clinical Center of Serbia, Clinic for Eye Diseases, Belgrade + School of Medicine, Belgrade)
Introduction/Objective. Evaluation of the optic nerve head (ONH) is an
inevitable procedure in the diagnosis of glaucoma. One of the most common
imaging techniques for a quantitative assessment of the topography of the ONH
is the Heidelberg retinal tomography II (HRT II). The aim of this study was
to determine quantitative stereometric parameters of the ONH by using the HRT
II and to investigate any damage of neuroretinal rim in children with
suspected glaucoma and compared these data with the group of adults with
suspected glaucoma. Methods. This comparative study included 167 (167 eyes)
children aged 11±3 years with suspected juvenile glaucoma and 175 adult
participants (175 eyes), aged 60±3 years, also with suspected glaucoma,
examined between January 2013 and April 2014. Optic nerve head topography and
retinal nerve fiber layer thickness measurements were assessed using a HRT
II. Results. Data analysis in this study showed that the average mean values
for children/adults were: disc area (mm2) 2.828±0.489/2.663±0.412 (p<0.001);
rim area (mm2) 1.873±0.391/1.667±0.275 (p<0.001); cup/disc area ratio
0.369±0.125/0.369±0.101 (p=0.530); mean retinal nerve fiber layer thickness
(mm) 0.223±0.078/0.219±0.055 (p=0.494). Statistically significant difference
in damage of neuroretinal rim, between children and adults, was found in
temporal (T) and temporal-inferior (Ti) segments. Conclusions. There were
differences in some of the investigated quantitative parameters of the ONH
between children and adults, as optic disc size, cup and rim area and rim
volume. By using MRA, difference in the damage of the neuroretinal rim, when
comparing children and adult optic discs appeared only in T and Ti segments,
which means that optic disc cupping has spread more in children than in
adults.
Keywords: Heidelberg retina tomography, optic disc, stereometric parameters, primary open angleglaucoma, juvenile glaucoma