Srpski arhiv za celokupno lekarstvo 2016 Volume 144, Issue 9-10, Pages: 521-526
https://doi.org/10.2298/SARH1610521P
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Streptococcus pneumoniae serotype distribution in Vojvodina before the introduction of pneumococcal conjugate vaccines into the national immunization program
Petrović Vladimir (Institute of Public Health of Vojvodina, Novi Sad + Faculty of Medicine, Novi Sad)
Šeguljev Zorica (Institute of Public Health of Vojvodina, Novi Sad + Faculty of Medicine, Novi Sad)
Ristić Mioljub (Institute of Public Health of Vojvodina, Novi Sad + Faculty of Medicine, Novi Sad)
Đekić-Malbaša Jelena (Institute of Public Health of Vojvodina, Novi Sad + Faculty of Medicine, Novi Sad)
Radosavljević Biljana (Institute of Public Health of Vojvodina, Novi Sad)
Medić Deana (Institute of Public Health of Vojvodina, Novi Sad + Faculty of Medicine, Novi Sad)
Mihajlović-Ukropina Mira (Institute of Public Health of Vojvodina, Novi Sad + Faculty of Medicine, Novi Sad)
Hadnađev Mirjana (Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica)
Gajić Ina (School of Medicine, Institute for Microbiology and Immunology, National Reference Laboratory for Streptococci, Belgrade)
Opavski Nataša (School of Medicine, Institute for Microbiology and Immunology, National Reference Laboratory for Streptococci, Belgrade)
Introduction. Streptococcus pneumoniae is the most common causative agent of
bacterial pneumonia and meningitis. Mandatory childhood immunization against
pneumococcal diseases is introduced in the new Law on Protection of
Population against Communicable Diseases in Serbia. Objective. The objective
of this study was to determine the prevalence of pneumococcal serotype
distribution in Vojvodina region before routine use of pneumococcal conjugate
vaccine in Serbia. Methods. A total of 105 isolates of Streptococcus
pneumoniae were collected in the period from January 2009 to April 2016.
Based on the results of serotyping in the National Reference Laboratory, we
analyzed distribution of circulating serotypes and coverage of conjugate and
23-valent polysaccharide pneumococcal vaccines in different age groups.
Results. Among 105 isolates, a total of 21 different serotypes of
Streptococcus pneumoniae were determined. The most frequent serotypes were 3
(21.9%), 19F (20.0%), and 14 (10.5%). The serotype coverage of pneumococcal
conjugate vaccines (PCV7, PCV10, and PCV13) was 48.6%, 54.3%, and 84.8%,
respectively, while pneumococcal polysaccharide vaccine (PPV23) covered 89.5%
of the total number of isolates in all age groups. Serotypes included in
PCV7, PCV10, and PCV13 represented 72.0%, 76.0%, and 88.0% of the total
number of isolates in children ≤5 years, respectively. Vaccine serotype
coverage of PCV13 and PPV23 ranged from 87.1% to 90.3% in adults 50-64 years
of age, and 77.8% to 85.2% in adults ≥65 years old. Conclusion. Serotype
distribution of Streptococcus pneumoniae in the population fairly overlaps
with the serotypes contained in pneumococcal vaccines, so that implementation
of childhood immunization is justified. The study was done in the Province of
Vojvodina but the findings may be applied to Serbia as a whole. [Projekat
Ministarstva nauke Republike Srbije, br. ON 175039]
This article has been corrected. Link to the correction 10.2298/SARH1612678E
Keywords: Streptococcus pneumoniae, serotypes, vaccine serotypes