Srpski arhiv za celokupno lekarstvo 2016 Volume 144, Issue 7-8, Pages: 450-455
https://doi.org/10.2298/SARH1608450V
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Capture the fracture - use of bone turnover markers in clinical practice
Vuksanović Miljanka (Zvezdara Clinical Hospital Center, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolic Diseases, Osteoporosis Unit, Belgrade)
Beljić-Živković Teodora (Zvezdara Clinical Hospital Center, Department of Internal Medicine, Division of Endocrinology, Diabetes and Metabolic Diseases, Osteoporosis Unit, Belgrade + School of Medicine, Belgrade)
Bone is a living tissue, metabolically very active, with the level of
turnover of about 10% per year. Bone remodeling is a well-balanced process of
bone resorption, induced by osteoclasts and bone formation maintained
osteoblasts. Loss of bone remodeling balance, with increased bone resorption,
leads to osteoporosis. Bone turnover markers are classified as markers of
bone formation and of bone resorption. During the growth and development of
skeleton, bone turnover markers show higher levels of activity than in the
adult period. The increase in biochemical markers peaks again in the
postmenopausal period, indicating accelerated bone remodeling. Bone mineral
density is an important predictor of an osteoporotic fracture. Timely
assessment of risk factors of osteoporosis and bone markers can detect
subjects with accelerated bone remodeling and osteoporosis. This may
introduce adequate therapy and prevent fracture.
Keywords: bone, bone markers, osteoporosis, fracture