doiSerbia

Allogeneic fetal stem cell transplantation to child with psychomotor retardation: A case report

Dajić Katerina (Clinical Centre of Kragujevac, Pediatric Clinic, Kragujevac)
Veličković Vesna (Clinical Centre of Kragujevac, Pediatric Clinic, Kragujevac)
Đurđević Predrag (Faculty of Medical Sciences, Kragujevac + Clinical Centre of Kragujevac, Internal Clinic, Kragujevac)
Simović Aleksandra M. (Clinical Centre of Kragujevac, Pediatric Clinic, Kragujevac + Faculty of Medical Sciences, Kragujevac)
Stojković Anđelka K. (Clinical Centre of Kragujevac, Pediatric Clinic, Kragujevac + Faculty of Medical Sciences, Kragujevac)

Introduction. The consequences of autologous and allogeneic stem cell transplantation (stem cells of hematopoiesis), applied in adults and children suffering from leukemia or some other malignant disease, are well-known and sufficiently recognizable in pediatric clinical practice regardless of the indication for the treatment. However, the efficacy of fetal stem cell transplantation is unrecognizable when the indications are psychomotor retardation and epilepsy. Case Outline. With the exception of neurological psychiatric problems, a boy aged 9.5 years was in good general health before transplantation with allogeneic fetal stem cells. The main aim of allogeneic fetal stem cell transplantation was treatment of psychomotor retardation and epilepsy. After 13 months of treatment, he was admitted to hospital in a very serious, life-threatening condition due to sepsis and severe pleuropneumonia. The humoral immunity in the boy was adequate, unlike cellular immunity. The immune imbalance in terms of predominance of T-suppressor lymphocytes contributes to delayed and late development of sepsis and severe pleuropneumonia. The boy still shows the same severity of psychomotor retardation, dyslalia, epilepsy, strabismus and amblyopia. Conclusion. Implementation of fetal stem cell therapy for unconfirmed indications abuses the therapeutic approach, harms patients, misleads parents, and brings financial harm to the healthcare system of any country, including Serbia.

Keywords: stem cells, transplantation, homologous, epilepsy, psychomotor disorders, costs