Srpski arhiv za celokupno lekarstvo 2016 Volume 144, Issue 7-8, Pages: 413-417
https://doi.org/10.2298/SARH1608413L
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Lymphoblastic lymphomas in children: A single-center experience from Serbia
Lazić Jelena 
(School of Medicine, Belgrade + University Children’s Hospital, Belgrade)
Janić Dragana (School of Medicine, Belgrade + University Children’s Hospital, Belgrade)
Krstovski Nada (School of Medicine, Belgrade + University Children’s Hospital, Belgrade)
Rodić Predrag (School of Medicine, Belgrade + University Children’s Hospital, Belgrade)
Milošević Goran (University Children’s Hospital, Belgrade)
Janković Srđa (University Children’s Hospital, Belgrade)
Brašanac Dimitrije (School of Medicine, Belgrade + School of Medicine, Institute of Pathology, Belgrade)
Dokmanović Lidija (School of Medicine, Belgrade + University Children’s Hospital, Belgrade)
Introduction. Intensive treatment protocols used for non-Hodgkin lymphoma in
children lead to eventfree survival rates ranging from 80% to 90%. However,
the results are less successful in developing countries. Lymphoblastic
lymphoma (LBL) is the second most frequent type of lymphoma in children,
contributing with about one third to all non-Hodgkin lymphoma in childhood.
Objective. The aim of the study was to evaluate the results of LBL treatment
in University Children’s Hospital (UCH), Belgrade. Methods. A retrospective
analysis of patient records at UCH from 1997 to 2015 was carried out in
patients aged 0-18 years, in whom the diagnosis of LBL had been established.
Twenty-two children were included in the analysis. Results. Mean age at
diagnosis was 10 years, with preponderance of male patients. All patients
were treated according to Berlin-Frankfurt-Münster-based chemotherapy
protocols. With median follow-up of 91.5 months, five-year probability of
event-free survival was 79.5% for all patients, while overall survival was
81.8%. Conclusion. Our results, although slightly inferior to those of
leading international groups, reflect a good treatment outcome in our
patients.
Keywords: pediatric, lymphoblastic lymphoma, Serbia, children
Projekat Ministarstva nauke Republike Srbije, br. 41004