Srpski arhiv za celokupno lekarstvo 2016 Volume 144, Issue 7-8, Pages: 408-412
https://doi.org/10.2298/SARH1608408S
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Rising incidence of childhood type 1 diabetes in Montenegro
Samardžić Mira (Institute for Children’s Diseases, Podgorica, Montenegro)
Popović Nataša (Institute for Children’s Diseases, Podgorica, Montenegro)
Terzić Nataša (Institute of Public Health of Montenegro, Podgorica, Montenegro)
Popović-Samardžić Milena (Institute of Public Health of Montenegro, Podgorica, Montenegro)
Nedović-Vuković Mirjana (Institute of Public Health of Montenegro, Podgorica, Montenegro)
Introduction. The incidence rate of childhood type1 diabetes continues to
rise across Europe by an average of approximately 3-4% per annum. Objective.
The aim of this study was to examine incidence and trends of type 1 diabetes
in children aged 0-14 years in Montenegro from 1997 to 2011. Methods. This
was a prospective study. Primary case ascertainment was from a diabetes
register, and a secondary independent data source was from hospital
notifications. Case ascertainment was 100% complete using the
capture-recapture method. Standardized incidence rates were calculated and
trends estimated using the Poisson regression. Results. A total of 298
children (157 boys and 141 girls) were diagnosed with type 1 diabetes before
15 years of age during 1997-2011. The mean age-standardized incidence was
15.0/100,000 persons (95% CI: 12.3-17.6) during this period, increasing from
11.7/100,000 in 1997 to 18.8/100,000 in 2011. The agespecific rates per
100,000 persons per year were 10.7, 17.2, and 18.2 at ages 0-4 years, 5-9
years, and 10-14 years, respectively. A significant linear trend in incidence
(p = 0.002) has been observed over time, with an average annual increase of
4.2%. The increase in incidence was present in both genders, with the largest
relative increase in the 0-4 years age group for boys (11.0%; p = 0.006).
Conclusion. The incidence of type 1 diabetes in Montenegro children continues
to increase. We need further monitoring and additional research in order to
explain the cause.
Keywords: type 1 diabetes, incidence, type 1 diabetes, children, Montenegro