Srpski arhiv za celokupno lekarstvo 2016 Volume 144, Issue 1-2, Pages: 81-84
https://doi.org/10.2298/SARH1602081Z
Full text ( 108 KB)
Cited by
A case of essential thrombocythemia and ankylosing spondylitis treated with a combination of anagrelide, disease-modifying antirheumatic drugs, and etanercept
Zeremski Vanja (University Hospital Magdeburg, Department of Hematology and Oncology, Magdeburg, Germany)
Savić Aleksandar (Clinical Center of Vojvodina, Clinic of Hematology, Novi Sad + Faculty of Medicine, Novi Sad)
Ilić Tatjana (Faculty of Medicine, Novi Sad + Clinical Center of Vojvodina, Clinic of Nephrology and Clinical Immunology, Novi Sad)
Milošević Ivana (Clinical Center of Vojvodina, Clinic of Hematology, Novi Sad + Faculty of Medicine, Novi Sad)
Maksimović Marina (Faculty of Medicine, Novi Sad + Special Hospital for Rheumatic Diseases, Novi Sad)
Vučković Biljana (Faculty of Medicine, Novi Sad + Center for Laboratory Medicine, Clinical Center of Vojvodina, Novi Sad)
Introduction. A high platelet count, or thrombocytosis, is either a reactive
process or a result of a myeloproliferative disorder. Ankylosing spondylitis
is a chronic inflammatory rheumatic disease affecting the spine and sometimes
peripheral joints in which reactive mild to moderate thrombocytosis is a
common finding. There have been no previously reported cases of essential
thrombocythemia associated with ankylosing spondylitis. Case Outline. We
report a case of a 32-year-old man with human leukocyte antigen B27-positive
ankylosing spondylitis and Janus kinase 2-positive essential thrombocythemia
who was treated first with a combination of anagrelide and disease-modifying
antirheumatic drugs and, after liver toxicity, with a combination of
anagrelide and etanercept (TNF-α antagonist). Both diseases were gradually
brought under control. Conclusion. Our case of ankylosing spondylitis and
essential thrombocythemia suggests that concomitant etanercept and anagrelide
therapy is safe, as well as effective.
Keywords: essential thrombocythemia, ankylosing spondylitis, antirheumatic agents