doiSerbia

Peripartum cardiomyopathy in a patient treated for acute myeloid leukemia

Čolović Nataša (School of Medicine, Belgrade + Clinical Center of Serbia, Clinic for Hematology, Belgrade)
Seferović Petar (School of Medicine, Belgrade + Clinic for Cardiology, Clinical Center of Serbia, Belgrade)
Plećić Miroslava (Health Center, Valjevo)
Vidović Ana (School of Medicine, Belgrade + Clinical Center of Serbia, Clinic for Hematology, Belgrade)
Suvajdžić Nada (School of Medicine, Belgrade + Clinical Center of Serbia, Clinic for Hematology, Belgrade)
Tomin Dragica (School of Medicine, Belgrade + Clinical Center of Serbia, Clinic for Hematology, Belgrade)

Introduction. Peripartum cardiomyopathy usually presents with systolic heart failure during the last months of pregnancy and up to five months postpartum. The disease is rare and can be fatal. Case Outline. We report a 30-year-old female who was diagnosed with acute myeloid leukemia, with maturation and cytogenetic finding of t(8;21)(q22;q22),del(9)(q22) in January 2004. She was treated with chemotherapy and achieved complete remission that lasts to date. She became pregnant and delivered a healthy newborn with caesarean section in 2009. Seven months later, she again became pregnant and delivered the second child with caesarean section in January 2011. Seven days after delivery she developed symptoms and signs of heart failure. Electrocardiogram showed sinus rhythm, low voltage and negative T-waves in inferior and lateral leads. Echocardiography revealed global left ventricular dysfunction with ejection fraction of 15%, with mobile thrombotic mass of 12 mm attached to the left ventricle wall. She was treated with both unfractionated and low-molecular heparin, diuretics, cardiotonics, and beta-blockers. Within six following weeks left ventricle systolic function improved up to 25-30%. The full clinical recovery was achieved in September 2013, resulting in absence of heart failure and left ventricular ejection fraction of 54%. Conclusion. Peripartum cardiomyopathy is a rare condition. The cause of cardiomyopathy is unknown, but it is believed that it could be triggered by various conditions and risk factors. Although the patient was treated with cardiotoxic drugs (doxorubicin and mitoxantrone) in permitted doses, they could have been contributory factors of myocardial damage. Close monitoring of cardiac function in the peripartal period might be beneficial in patients treated with cardiotoxic drugs.

Keywords: peripartum, cardiomyopathy, acute myeloid leukemia

Projekat Ministarstva nauke Republike Srbije, br. 175080 I br. OI 175034