Srpski arhiv za celokupno lekarstvo 2016 Volume 144, Issue 1-2, Pages: 38-45
https://doi.org/10.2298/SARH1602038S
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Clinical trial/experimental study (consort compliant): Optimal time period to achieve the effects on synbiotic-controlled wheezing and respiratory infections in young children
Stojković Anđelka (Clinical Center Kragujevac, Pediatric Clinic, Kragujevac + Faculty of Medical Sciences, Kragujevac)
Simović Aleksandra (Clinical Center Kragujevac, Pediatric Clinic, Kragujevac + Faculty of Medical Sciences, Kragujevac)
Bogdanović Zoran (State University of Novi Pazar, Novi Pazar)
Banković Dragić (State University of Novi Pazar, Novi Pazar)
Poskurica Mina (Faculty of Medical Sciences, Kragujevac)
Introduction. Urban life is often followed by immune dysfunction and loss of
immune tolerance in the youngest children. Objective. The study aimed to
determine optimal time efficiency of a synbiotic (5.109 Lactobacillus
acidophilus Rosell-52, Bifidobacterium infantis Rosell-33, Bifidobacterium
bifidum Rosell-71) in controlling respiratory infections and wheezing
disease. Methods. We randomly selected a group of children younger than five
years, hospitalized earlier, and classified them into three groups. Results.
The incidence of respiratory infection before the study was once a month,
while after a threemonth supplementation with the synbiotic children rarely
suffered from respiratory infections, and the state was maintained after
six-month and nine-month supplementations with the synbiotic. The decreased
incidence of respiratory infections was followed by a falling incidence of
concomitant wheezing. A significant increase in tIgA serum was observed in
all groups for only three months, the increase being the highest in children
with recurrent respiratory infections accompanied by wheezing. After a
ninemonth administration of the synbiotic, total IgE serum was lower in all
groups of patients. Conclusion. The optimal duration of administration of
the synbiotic containing three probiotic cultures to provide effective
control of the frequency of respiratory infections was three months, and six
months were required to establish control of the frequency of wheezing. This
synbiotic is useful for immunomodulation in children and is well-tolerated
in young children.
Keywords: biodiversity, synbiotics, wheezing, respiratory tract infections, children