doiSerbia

Adrenocortical carcinoma’s incidence and mortality in central Serbia

Jovanović Milan D. (Clinical Center of Serbia, Center for Endocrine Surgery, Belgrade)
Živaljević Vladan R. (Clinical Center of Serbia, Center for Endocrine Surgery, Belgrade + School of Medicine, Belgrade)
Diklić Aleksandar D. (Clinical Center of Serbia, Center for Endocrine Surgery, Belgrade + School of Medicine, Belgrade)
Slijepčević Nikola A. (Clinical Center of Serbia, Center for Endocrine Surgery, Belgrade)
Taušanović Katarina M. (Clinical Center of Serbia, Center for Endocrine Surgery, Belgrade)
Stevanović Ksenija S. (Clinical Center of Serbia, Clinic for Vascular and Endovascular Surgery, Belgrade)
Paunović Ivan R. (Clinical Center of Serbia, Center for Endocrine Surgery, Belgrade + School of Medicine, Belgrade)

Introduction/Objective. Adrenocortical carcinomas (ACCs) are very rare tumors with grave prognosis despite multimodal treatment. The aim of our study was to determine the incidence and mortality of ACCs in Central Serbia. Methods. The study period was from 1999 to 2012. We used data from the Cancer Registry of Central Serbia. Incidence and mortality rates were sex- and age-standardized according to Segi’s world population. Results. In the defined period of the study, 128 patients with a diagnosis of ACC were registered and the female-to-male ratio was 1.3:1. The median age of affected individuals was 42.3 years. There were two main age peaks – one in childhood (0–9 years), and the other in the fifth and sixth decade of life. In this period, the average standardized incidence rate of ACC amounted to two per million people with slightly increasing trend. The largest number of male patients with ACC (22; 39.2%) was registered in the age group of 0–9 years, while the largest number of patients in females was shown to be in the age group of 40–49 years (29; 40.3%). During the study period, there were 35 deaths registered in patients with ACC (mean age of 61.2 years). The average mortality rate of ACC was 0.3 per million people. The male-to-female ratio was 1.5:1. Most fatal outcomes were registered in the age groups of 50–59 and 60–69 years, so 91.4% of all deaths took place in the age groups 50+. Conclusion. ACC is an extremely rare tumor that occurs more often in women than in men. However, fatal outcomes occur more frequently in males.

Keywords: adrenocortical carcinoma, incidence, mortality

Project of the Ministry of Education, Science and Technological Development of the Republic of Serbia, Grant no. 175042