Srpski arhiv za celokupno lekarstvo 2016 Volume 144, Issue 1-2, Pages: 6-9
https://doi.org/10.2298/SARH1602006S
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Carotid artery wall stiffness is increased in patients with small vessel disease: A case-control study
Salihović-Hajdarević Denisa (University Clinical Center Tuzla, Department of Neurology, Tuzla, Bosnia and Herzegovina)
Pavlović Aleksandra M. (School of Medicine, Belgrade + Clinical Center of Serbia, Neurology Clinic, Belgrade)
Smajlović Dževdet (University Clinical Center Tuzla, Department of Neurology, Tuzla, Bosnia and Herzegovina)
Podgorac Ana (School of Medicine, Belgrade + Clinical Center of Serbia, Neurology Clinic, Belgrade)
Jovanović Zagorka (School of Medicine, Belgrade + Clinical Center of Serbia, Neurology Clinic, Belgrade)
Švabić-Međedović Tamara (School of Medicine, Belgrade + Clinical Center of Serbia, Neurology Clinic, Belgrade)
Čovičković-Šternić Nadežda (School of Medicine, Belgrade + Clinical Center of Serbia, Neurology Clinic, Belgrade)
Introduction. Cerebral ischemic small-vessel disease (SVD), causing lacunar
infarcts and white matter hyperintensities on brain magnetic resonance
imaging (MRI), is a progressive disease associated with an increased risk of
stroke, dementia and death. Increased arterial stiffness has been associated
with ischemic stroke and cerebral SVD independently of common vascular risk
factors. Objective. The aim of the study was to analyze arterial stiffness in
our patients with symptomatic SVD. Methods. In a cross-sectional study design
we included 30 patients with clinical and MRI evidence of cerebral SVD and 30
age-, gender- and risk factor-matched control subjects with no neurological
diseases. Patients were evaluated at the Ultrasound Laboratory at the
Neurology Clinic, Clinical Center of Serbia in Belgrade, during a three-month
period (from September 1st to December 1st 2012). Baseline demographic and
vascular risk factors were recorded. All patients underwent standard carotid
ultrasound scans with measuring of intima-media thickness (IMT) and analysis
of atheromatous plaques. Internal carotid artery stiffness was evaluated with
the use of e-tracking option as beta stiffness index (BSI) value. Results.
There were no differences between study groups in regard to degree of carotid
stenosis and type of carotid plaques (p>0.05). Patients in SVD group had
significantly higher mean IMT (p=0.0093) and mean BSI (p<0.0001) than
subjects in the control group. No significant correlation was detected
between IMT and BSI in SVD group (r=0.168; p=0.376). Brain lesions severity
correlated with BSI (r=0.733; p<0.0001). Conclusion. Arterial stiffness is
increased in symptomatic patients with SVD, independently of vascular risk
factors and IMT.
Keywords: carotid artery, intima-media thickness, arterial stiffness, beta stiffness index
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