Srpski arhiv za celokupno lekarstvo 2015 Volume 143, Issue 11-12, Pages: 701-706
https://doi.org/10.2298/SARH1512701H
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Parental factors associated with intrauterine growth restriction
Hăşmăşanu Monica G. (Iuliu Haţieganu University of Medicine and Pharmacy, Department of Neonatology, Cluj-Napoca, Romania + Emergency Clinical County Hospital, Department of Neonatology, Cluj-Napoca, Romania)
Bolboacă Sorana D. (Iuliu Haţieganu University of Medicine and Pharmacy, Department of Medical Informatics and Biostatistics, Cluj-Napoca, Romania)
Drugan Tudor C. (Iuliu Haţieganu University of Medicine and Pharmacy, Department of Medical Informatics and Biostatistics, Cluj-Napoca, Romania)
Matyas Melinda (Iuliu Haţieganu University of Medicine and Pharmacy, Department of Neonatology, Cluj-Napoca, Romania + Emergency Clinical County Hospital, Department of Neonatology, Cluj-Napoca, Romania;)
Zaharie Gabriela C. (Iuliu Haţieganu University of Medicine and Pharmacy, Department of Medical Informatics and Biostatistics, Cluj-Napoca, Romania)
Introduction. Linear growth failure is caused by multiple factors including
parental factors. Objective. The aim of this study was to evaluate parental
risk factors for intrauterine growth restriction (IUGR) on a population of
Romanian newborn infants in a tertiary level maternity facility for a period
of 2.5 years. Methods. A retrospective matched case-control study was
conducted in the Emergency County Hospital of Cluj-Napoca, a university
hospital in North-Western Romania. The sample was selected from 4,790 infants
admitted to the Neonatal Ward at 1st Gynecology Clinic between January 2012
and June 2014. Results. The age of mothers was significantly lower in the
IUGR group compared to controls (p=0.041). A significantly higher percentage
of mothers had hypertension in the IUGR group compared to those in the
control group (p<0.05). No other significant differences were identified with
regard to the investigated characteristics of mothers between IUGR infants
compared to controls (p>0.13). The age of fathers of infants with IUGR proved
significantly lower compared to controls (p=0.0278). The analysis of infants’
comorbidities revealed no significant difference between groups for
respiratory distress, hyperbilirubinemia, hypocalcaemia, and heart failure
(p>0.27). Intracranial hemorrhage, necrotizing enterocolitis and hypoglycemia
were significantly higher in the IUGR group compared to controls. The
logistic regression identified hypertension as a significant risk factor for
IUGR (OR=2.4, 95% CI [1.3-4.5]). Conclusion. Although the age of the mothers
and fathers proved significantly lower in the IUGR group compared to
controls, only hypertension in the mothers proved significant risk factors
for IUGR.
Keywords: intrauterine growth restriction, parental characteristics, risk factor