Srpski arhiv za celokupno lekarstvo 2015 Volume 143, Issue 7-8, Pages: 487-493
https://doi.org/10.2298/SARH1508487B
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The stem-cell application in ischemic heart disease: Basic principles, specifics and practical experience from clinical studies
Banović Marko (School of Medicine, Belgrade + Clinical Center of Serbia, Cardiology Clinic, Belgrade)
Obradović Slobodan (Military Medical Academy, Belgrade)
Beleslin Branko (School of Medicine, Belgrade + Clinical Center of Serbia, Cardiology Clinic, Belgrade)
Longer life duration, different clinical presentations of coronary disease,
as well as high incidence of comorbidity in patients with ischemic heart
disease have led to an increase in the incidence of ischemic heart failure.
Despite numerous and new treatment methods that act on different
pathophysiological mechanisms that cause heart failure, and whose aim is to
slowdown or stop the progression of this devastating disease, morbidity and
mortality in these patients remain high. These facts have firstly led to the
introduction of the experimental, and then clinical studies with the
application of stem cells in patients with ischemic heart disease. Previous
studies have shown that the application of stem cells is a feasible and safe
method in patients with acute coronary syndrome, as well as in patients with
chronic ischemic cardiomyopathy, but the efficacy of these methods in both of
the abovementioned clinical syndromes has yet to be established. This review
paper outlines the basic principles of treatment of ischemic heart disease
with stem cells, as well as the experience and knowledge gained in previous
clinical studies.
Keywords: stem cells, clinical studies, ischemic disease, cardiomyopathy