Srpski arhiv za celokupno lekarstvo 2015 Volume 143, Issue 3-4, Pages: 205-209
https://doi.org/10.2298/SARH1504205N
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Cited by
Management of brain metastasis in a patient with advanced epithelial ovarian carcinoma by gamma-knife radiosurgery
Nikolaou Marinos (General Hospital of Agios Nikolaos, Department of Obstetrics and Gynecology, Lasithi, Crete, Greece)
Stamenković Srđan (University Women’s Hospital in Neuenheimer Feld, Department of Obstetrics and Gynecology, Heidelberg, Germany)
Stergiou Christos (Hygeia Hospital, Marousi, Ganmma Knife Department, Athens, Greece)
Skarleas Christos (Hygeia Hospital, Marousi, Ganmma Knife Department, Athens, Greece)
Torrens Michael (Hygeia Hospital, Marousi, Ganmma Knife Department, Athens, Greece)
Introduction. Brain metastases from epithelial ovarian cancer (EOC) are rare
events. We present a rare case of single ovarian cancer metastasis to the
brain treated with gamma-knife radiosurgery (GKRS). Case Outline. A
65-year-old woman with advanced EOC presented with severe neurologic
symptoms. A single brain metastasis of 3.2 cm with surrounding edema in the
left parietal lobe was detected by brain magnetic resonance imaging (MRI)
scan during the work-up. The decision to perform GKRS was due to a surgical
inaccessibility of intracranial lesion. Twelve weeks after the procedure, the
MRI scan showed reduction in the diameter of brain metastasis and surrounding
edema and the patient returned to good mental and motor performance. The
patient survived for 22 months following treatment and died from a
progressive intra-abdominal disease. Prognosis of ovarian cancer patients
with brain metastases is generally poor regardless of treatment. Conclusion.
Our case shows that GKRS as primary treatment modality for the control of
ovarian cancer metastases to the brain was effective and can be considered as
a treatment of choice if international selection criteria are followed.
Keywords: gamma-knife stereotactic radiosurgery, solitary brain metastasis, ovarian carcinoma