Srpski arhiv za celokupno lekarstvo 2015 Volume 143, Issue 3-4, Pages: 146-152
https://doi.org/10.2298/SARH1504146F
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Risk factors for the development of metabolic syndrome in obese children and adolescents
Folić Nevena (Clinical Centre Kragujevac, Pediatric Clinic, Kragujevac)
Folić Marko (Clinical Centre Kragujevac, Department of Clinical Pharmacology, Kragujevac + Faculty of Medical Sciences, Kragujevac)
Marković Slavica (Clinical Centre Kragujevac, Pediatric Clinic, Kragujevac + Faculty of Medical Sciences, Kragujevac)
Anđelković Marija (Faculty of Medical Sciences, Kragujevac + Clinical Centre Kragujevac, Department of Laboratory Diagnostics, Kragujevac)
Janković Slobodan (Clinical Centre Kragujevac, Department of Clinical Pharmacology, Kragujevac + Faculty of Medical Sciences, Kragujevac)
Introduction. High prevalence of metabolic syndrome (MetS) in children and
adolescents is a great concern of the modern society. Objective. Our aim was
to determine the influence of previously investigated, but also and
potentially novel risk factors for the development of metabolic syndrome in
children and adolescents. Methods. Observational case-control clinical study
was conducted involving children and adolescents with obesity/metabolic
syndrome, treated on inpatient basis from January 2008 to January 2012 at the
Pediatric Clinic of the Clinical Centre Kragujevac, Kragujevac, Serbia. The
group of “cases” (n=28) included patients aged 10-16 years with the diagnosis
of metabolic syndrome according to the International Diabetes Federation
(IDF) criteria, while the control group included twice as many obese patients
(n=56) matched to the compared group. Results. Presence of maternal
gestational diabetes (ORadjusted: 39.426; 95% CI: 1.822-853.271; p=0.019),
and/or lack of breastfeeding in the first six months of life (ORadjusted:
0.079; 95% CI: 0.009-0.716; p=0.024) were significant predictors for
developing MetS. Also, microalbuminuria is associated with MetS in obese
children and adolescents (ORadjusted: 1.686; 95% CI: 1.188-2.393; p=0.003).
Conclusion. Presence of maternal gestational diabetes and/or lack of infant
breastfeeding are considered as relevant factors that may contribute to the
increased risk of developing MetS syndrome, while microalbuminuria is
frequently associated with MetS in obese children and adolescents.
Keywords: metabolic syndrome, child obesity, adolescent obesity, risk factors
Projekat
Ministarstva nauke Republike Srbije, br. 175007