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Srpski arhiv za celokupno lekarstvo 2015 Volume 143, Issue 3-4, Pages: 146-152
https://doi.org/10.2298/SARH1504146F
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Risk factors for the development of metabolic syndrome in obese children and adolescents

Folić Nevena ORCID iD icon (Clinical Centre Kragujevac, Pediatric Clinic, Kragujevac)
Folić Marko ORCID iD icon (Clinical Centre Kragujevac, Department of Clinical Pharmacology, Kragujevac + Faculty of Medical Sciences, Kragujevac)
Marković Slavica ORCID iD icon (Clinical Centre Kragujevac, Pediatric Clinic, Kragujevac + Faculty of Medical Sciences, Kragujevac)
Anđelković Marija (Faculty of Medical Sciences, Kragujevac + Clinical Centre Kragujevac, Department of Laboratory Diagnostics, Kragujevac)
Janković Slobodan ORCID iD icon (Clinical Centre Kragujevac, Department of Clinical Pharmacology, Kragujevac + Faculty of Medical Sciences, Kragujevac)

Introduction. High prevalence of metabolic syndrome (MetS) in children and adolescents is a great concern of the modern society. Objective. Our aim was to determine the influence of previously investigated, but also and potentially novel risk factors for the development of metabolic syndrome in children and adolescents. Methods. Observational case-control clinical study was conducted involving children and adolescents with obesity/metabolic syndrome, treated on inpatient basis from January 2008 to January 2012 at the Pediatric Clinic of the Clinical Centre Kragujevac, Kragujevac, Serbia. The group of “cases” (n=28) included patients aged 10-16 years with the diagnosis of metabolic syndrome according to the International Diabetes Federation (IDF) criteria, while the control group included twice as many obese patients (n=56) matched to the compared group. Results. Presence of maternal gestational diabetes (ORadjusted: 39.426; 95% CI: 1.822-853.271; p=0.019), and/or lack of breastfeeding in the first six months of life (ORadjusted: 0.079; 95% CI: 0.009-0.716; p=0.024) were significant predictors for developing MetS. Also, microalbuminuria is associated with MetS in obese children and adolescents (ORadjusted: 1.686; 95% CI: 1.188-2.393; p=0.003). Conclusion. Presence of maternal gestational diabetes and/or lack of infant breastfeeding are considered as relevant factors that may contribute to the increased risk of developing MetS syndrome, while microalbuminuria is frequently associated with MetS in obese children and adolescents.

Keywords: metabolic syndrome, child obesity, adolescent obesity, risk factors

Projekat Ministarstva nauke Republike Srbije, br. 175007