doiSerbia

Non-Hodgkin lymphomas in childhood: How to move on?

Dokmanović Lidija (Faculty of Medicine, Belgrade + University Children’s Hospital, Department of Hematology and Oncology, Belgrade)
Rodić Predrag (University Children’s Hospital, Department of Hematology and Oncology, Belgrade)
Krstovski Nada (Faculty of Medicine, Belgrade + University Children’s Hospital, Department of Hematology and Oncology, Belgrade)
Lazić Jelena (Faculty of Medicine, Belgrade + University Children’s Hospital, Department of Hematology and Oncology, Belgrade)
Janić Dragana (Faculty of Medicine, Belgrade + University Children’s Hospital, Department of Hematology and Oncology, Belgrade)

Non-Hodgkin lymphomas of childhood represent a diverse group of neoplasms with different clinical, pathological, immunophenotypical and genetic features. A vast majority of childhood non-Hodgkin lymphomas could be classified into one of the three major histological subgroups: mature B-cell neoplasms, lymphoblastic lymphomas or anaplastic large cell lymphomas. Modern therapeutic strategies lead to cure in more than 80% of patients. Conversely, refractory diseases, as well as disease relapse convey a dismal prognosis. This fact requires much better stratification based on prognostic markers which would ideally recognize distinct groups of patients requiring different therapeutic regimens. Defining novel diagnostic and prognostic markers should improve diagnosis and prognosis as well as patient follow-up. It should also allow introduction of individually tailored treatment regimens in selected groups of patients with non-Hodgkin lymphomas, with the main goal of improving treatment results and decreasing short- and long-term complications.

Keywords: non-Hodgkin lymphoma, children, classification, diagnosis, prognosis, treatment

Projekat Ministarstva nauke Republike Srbije, br. 41004