Srpski arhiv za celokupno lekarstvo 2014 Volume 142, Issue 5-6, Pages: 342-346
https://doi.org/10.2298/SARH1406342N
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Thrombolysis of occluded femoropopliteal graft with locally delivered human plasmin
Nenezić Dragoslav (Cardiovascular Institute “Dedinje”, Belgrade + School of Medicine, Belgrade)
Radak Đorđe (Cardiovascular Institute “Dedinje”, Belgrade + School of Medicine, Belgrade)
Jocić Dario (Cardiovascular Institute “Dedinje”, Belgrade + School of Medicine, Belgrade)
Gajin Predrag (Cardiovascular Institute “Dedinje”, Belgrade + School of Medicine, Belgrade)
Tanasković Slobodan 
(Cardiovascular Institute “Dedinje”, Belgrade + School of Medicine, Belgrade)
Novaković Aleksandra (Faculty of Pharmacy, Belgrade)
Matić Predrag (Cardiovascular Institute “Dedinje”, Belgrade + School of Medicine, Belgrade)
Introduction. Acute lower limb ischemia results from thrombosis or
embolization of diseased native artery or previously implanted bypass graft.
When this occurs, several options are available to restore blood flow:
catheter-directed thrombolysis, mechanical thrombectomy or open surgery.
Fundamental reasons to apply percutaneous interventions are avoiding open
procedures in high risk patients, and avoiding difficult dissection through
scar tissue. Case Outline. A 67-year-old male was admitted at our Institution
for critical limb ischemia. After performed angiography the diagnosis of
occluded femoropopliteal graft was established. Occlusion was resolved by
catheter-directed thrombolysis with plasmin. Culprit lesions were treated by
angioplasty. Conclusion. Our patient underwent a successful thrombolysis of
occluded femoropopliteal graft with locally-delivered human plasmin.
Keywords: percutaneous intervention, catheter-directed thrombolysis, human plasmin, femoropopliteal bypass