Srpski arhiv za celokupno lekarstvo 2014 Volume 142, Issue 5-6, Pages: 286-290
https://doi.org/10.2298/SARH1406286M
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Changes in the retrobulbar hemodynamic parameters after decreasing the elevated intraocular pressure in primary open-angle glaucoma patients
Marjanović Ivan (School of Medicine, Belgrade + Clinical Center of Serbia, Eye Clinic, Belgrade)
Martinez Antonio (Instituto Gallego de Oftalmologia, Clinical Research Department, Science Research and Sports, Santiago de Compostela, La Coruna, Spain)
Marjanović Marija (School of Medicine, Belgrade + Clinical Center of Serbia, Cardiology Clinic, Belgrade)
Milić Nataša (School of Medicine, Institute for Medical Statistics and Informatics, Belgrade)
Kontić Đorđe (School of Medicine, Belgrade + Clinical Center of Serbia, Eye Clinic, Belgrade)
Hentova-Senćanić Paraskeva (School of Medicine, Belgrade + Clinical Center of Serbia, Eye Clinic, Belgrade)
Marković Vujica (School of Medicine, Belgrade + Clinical Center of Serbia, Eye Clinic, Belgrade)
Božić Marija (School of Medicine, Belgrade + Clinical Center of Serbia, Eye Clinic, Belgrade)
Introduction. Ocular blood flow (OBF) disturbances could be involved both in
the pathogenesis and in progression of glaucomatous damage. Objective. The
aim of the study was to compare the retrobulbar hemodynamic parameters in the
ophthalmic artery (OA), central retinal artery (CRA) and short posterior
cilliary arteries (SPCA) after decreasing the elevated intraocular pressure
(IOP) in primary open-angle glaucoma (POAG) patients by using color Doppler
imaging (CDI). Methods. We examined 60 patients (21 male and 39 female) with
diagnosed and treated POAG. Thirtynine patients had increased IOP (>25 mm
Hg). Peak-systolic velocity (PSV), end-diastolic velocity (EDV), Pourcelot
resistance index (RI), and pulsatility index (PI) were assessed in the OA,
CRA, and SPCA. IOP was measured both with the Goldmann Applanation tonometer
(GAT) and with the Dynamic Contour tonometer (DCT), three times respectively.
Ocular pulse amplitude (OPA) was measured using DCT. Results. The retrobulbar
parameters between the baseline and after IOP reduction showed no difference
in measurements. After Bonferroni correction (p≤0.0056, alpha/9) statistical
significance was recorded only in the following retrobulbar hemodynamic
parameters; DCT (29.8±6.2 vs. 15.5±5.0), GAT (33.8±9.0 vs. 15.0±6.6) and OPA
measurements (4.3±1.0 vs. 3.0±1.6), as compared to the baseline. There was no
correlation between the changes in IOP measured with either DCT or GAT and
changes in the hemodynamic parameters (p>0.05 for all). Pearson correlation
coefficient (95% CI) showed very good correlation for IOP measurements
between DCT and GAT: at baseline 0.83 (0.71 to 0.90) and at the end 0.71
(0.55 to 0.83); p<0.0001 for both measurements, but without any difference
between them (p>0.05). Conclusion. There was a lack of correlation between
the changes in IOP measured with either DCT or GAT and the changes in the
hemodynamic parameters.
Keywords: retrobulbar vessels, color Doppler imaging, elevated intraocular pressure, glaucoma