Srpski arhiv za celokupno lekarstvo 2014 Volume 142, Issue 3-4, Pages: 184-188
https://doi.org/10.2298/SARH1404184S
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Preventive effect of ursodeoxycholic acid on parenteral nutrition-associated liver disease in infants
Simić Dušica (University Children’s Hospital, Belgrade + Faculty of Medicine, Belgrade)
Milojević Irina (University Children’s Hospital, Belgrade)
Bogićević Dragana (University Children’s Hospital, Belgrade + Faculty of Medicine, Belgrade)
Milenović Miodrag (Center for Anesthesiology and Resuscitation, Emergency Center, Clinical Center of Serbia, Belgrade)
Radlović Vladimir (University Children’s Hospital, Belgrade)
Drašković Biljana (Clinic of Pediatric Surgery, Institute for Child and Youth Health Care, Novi Sad + Faculty of Medicine, Novi Sad)
Uram-Benka Anna (Clinic of Pediatric Surgery, Institute for Child and Youth Health Care, Novi Sad + Faculty of Medicine, Novi Sad)
Sinđić Sanja (University Children’s Hospital, Belgrade + Faculty of Medicine, Belgrade)
Maksimović Ružica (Faculty of Medicine, Belgrade + Center for MRI, Clinical Center of Serbia, Belgrade)
Introduction. Parenteral nutrition-associated cholestasis is well recognized
phenomenon in the term and preterm infant receiving long-term parenteral
nutrition. Objectives. The aim of this study was to evaluate the effect of
ursodeoxycholic acid (UDCA) use on cholestasis in newborns on prolonged TPN.
Methods. A total of 56 infants were enrolled in this retrospective study:
control group consisted of lower (1500 g) birth weight infants (n=30), as
well as the group of pediatric (n=11) and surgical patients (n=15) treated
with UDCA. Blood chemistries were obtained two times weekly. Results. All of
56 newborns developed cholestasis but duration of parenteral nutrition (PN)
before onset of cholestasis was significantly longer in UDCA treated
patients. Average duration of PN before the onset of cholestasis in control
group of patients was 25 days in distinction from treated pediatric and
surgical patients (39 and 34 days, respectively). The peak serum conjugated
bilirubin (CB), AST, ALT and alkaline phosphatase (AP) levels were
significantly lower in the treated groups. There was no significant
difference among treated pediatric and surgical patients and between lower
and higher birth weight infants considering the CB, ALT, AST and AP peak.
Duration of cholestasis was significantly decreased in all treated groups.
There was a significant difference in time needed to achieve complete enteral
intake between pediatric and surgical patient group. Conclusion. Cholestasis
developed significantly later in treated groups than in the controls. UDCA
appears to be very successful in reducing the symptoms of cholestasis. The
difference in efficacy of UDCA treatment between lower and higher birth
weight infants could not be proven.
Keywords: parenteral nutrition, cholestasis, infants, ursodeoxycholic acid