Srpski arhiv za celokupno lekarstvo 2014 Volume 142, Issue 1-2, Pages: 106-112
https://doi.org/10.2298/SARH1402106J
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Current concepts of pathophysiology, epidemiology and classification of pruritus
Jovanović Marina (Faculty of Medicine, Novi Sad + Clinic of Dermatovenereology Diseases, Clinical Center of Vojvodina, Novi Sad)
Discovery of pruritus-specific mediators and receptors facilitated the
neurobiological concept of pruritus: itch-specific (histamine-dependent and
histamine-independent C-fibers); itch-specific receptors on cutaneous and
spinal neurons; “dialogue“ between the pruritus-specific neurons and cells in
the skin; peripheral and central mediation of pruritus; functional
“pruritus-specific matrix” in the brain with a role of pruritus center. In
10%-50% of persons without skin diseases, pruritus is considered the
manifestation of a systemic disorder. Identification of pruritus within
autoimmune and inflammatory diseases in dermatology is based on the clinical
picture and nature of the underlying disease, implying the development of
pruritus on primarily and/or secondarily inflamed skin. In the internal
medicine, pruritus commonly presents on primarily non-inflamed skin.,
involvement of the skin and gastrointestinal tract are two independent risk
factors of pruritus in systemic sclerosis, and of anal/vulvar pruritus.
Classification combines etiological and clinical criteria and should be
considered the only segment of a comprehensive approach to pruritus of
unknown origin.
Keywords: pruritus, skin diseases, prevalence, comorbidity
Projekat Ministarstva nauke Republike Srbije, br. 172058