Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 11-12, Pages: 732-737
https://doi.org/10.2298/SARH1312732V
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Natural evolution of experimental vitreous hemorrhage and effects of corticosteroids on its course
Vuković Dragan (Medicinski fakultet, Beograd + Klinički centar Srbije, Klinika za očne bolesti, Beograd)
Introduction. The course and prognosis of vitreous hemorrhage (VH) are
difficult to predict in spite of so far published experimental and clinical
studies. Objective. The goal of this study was to follow the course and
evaluate prognosis of vitreous hemorrhage. Methods. The experiment was
performed on 19 Chinchilla rabbits (Oryctolagus cuniculus), both males and
females (38 eyes), weighing 2500-3000 g, which were treated with autologous
blood (B) from marginal ear vein - the first group, and the second group was
treated with both blood and corticosteroids (B+CS). The course of vitreous
hemorrhage was examined. Results. Our results have shown that the cellular
reaction to vitreous hemorrhage is different, compared to hemorrhage in
other types of tissue, which is due to absence of an early polymorphonuclear
cellular reaction. Number of cells within vitreous body is very low.
Conclusion. Vitreous hemorrhage has unusual course followed by a small
number of cells (mostly poly-morphonuclear cells). This is most important
fact why VH is cleared very slowly (about 6 to 9 weeks). CS has moderate
influence on the acceleration of VH absorption.
Keywords: vitreous hemorrhage, natural course, corticosteroids, rabbits