Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 9-10, Pages: 667-670
https://doi.org/10.2298/SARH1310667M
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Chlorpromazine-induced status epilepticus: A case report
Momčilović-Kostadinović Dragana (Klinika za neurologiju i psihijatriju za decu i omladinu, Beograd)
Simonović Periša (Institut za mentalno zdravlje, Beograd)
Kolar Dušan (Klinika za neurologiju i psihijatriju za decu i omladinu, Beograd)
Jović Nebojša (Klinika za neurologiju i psihijatriju za decu i omladinu, Beograd + Medicinski fakultet, Beograd)
Introduction. It is largely known that some antipsychotic agents could have
proconvulsive and proepileptogenic effects in some patients and could induce
EEG abnormalities as well. However, the association of status epilepticus
with certain antipsychotic drugs has been very rarely reported. Case Report.
A case of an 18-year-old adolescent girl, with chlorpromazine therapy started
for anxiety-phobic disorder was reported. Her personal history disclosed
delayed psychomotor development. Shortly after the introduction of the
neuroleptic chlorpromazine therapy in minimal daily dose (37.5 mg), she
developed myoclonic status epilepticus, confirmed by the EEG records.
Frequent, symmetrical bilateral myoclonic jerks and altered behavior were
associated with bilateral epileptiform discharges of polyspikes and
spike-wave complexes. This epileptic event lasted 3.5 hours and it was
stopped by the parenteral administration of valproate and lorazepam; she was
EEG monitored until stable remission. Status epilepticus as initial epileptic
event induced by neuroleptic agent was not previously reported in our
national literature. Conclusion. Introduction of chlorpromazine to a patient
without history of seizures is associated with the evolution of an epileptic
activity, including the occurrence of status epilepticus. Clinical evaluation
of the risk factors possibly related to chlorpromazine-induced seizure is
recommended in individual patients before administering this drug.
Keywords: chlorpromazine, myoclonic status epilepticus, adolescents