Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 9-10, Pages: 640-647
https://doi.org/10.2298/SARH1310640D
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Risk factors of nosocomial infections caused by piperacillin-tazobactam resistant Pseudomonas aeruginosa
Đorđević Zorana (Klinički centar Kragujevac, Klinika za infektivne bolesti, Kragujevac)
Gajović Olgica 
(Klinički centar Kragujevac, Klinika za infektivne bolesti, Kragujevac + Medicinski fakultet, Kragujevac)
Mijailović Željko (Klinički centar Kragujevac, Klinika za infektivne bolesti, Kragujevac + Medicinski fakultet, Kragujevac)
Ilić Aleksandra (Medicinski fakultet, Kosovska Mitrovica)
Stolić Radojica (Medicinski fakultet, Kosovska Mitrovica)
Introduction. Pseudomonas aeruginosa is a common cause of serious infections
in hospitalized patients and is associated with high rates of hospital
morbidity and mortality. Objective. The aim of this study was to identify the
risk factors of nosocomial infections caused by piperacillintazobactam
resistant P. aeruginosa (PTRPA). Methods. A casecontrol study was conducted
in the Clinical Centre Kragujevac from January 2010 to December 2011.
Results. In the observed period, 79 (38.16%) patients had PT RPA infections,
while 128 (61.84%) patients had infections caused by
piperacillintazobactamsensitive P. aeruginosa (PTSPA). Pneumonia was more
frequently found in the PTRPA group (55.70%) (p<0.05), whereas urinary tract
infections were more frequent in the group of patients with PTSPA infections
(26.56%) (p<0.01). Multivariate analysis was used to identify an injury on
admission (OR=3.089; 95%CI=1.4386.635; p=0.004), administration of imipenem
(OR=15.027; 95%CI=1.778 127.021; p=0.013), meropenem (OR=2.618; 95%CI=1.030
6.653; p=0.043), ciprofloxacin (OR=3.380; 95%CI=1.4128.090; p=0.006),
vancomycin (OR=4.294; 95%CI=1.47712.479; p=0.007), piperacillintazobactam
(OR=4.047; 95%CI=1.39511.742; p=0. 010) as independent risk factors
associated with PTRPA infection. Conclusion. In hospitalized patients, the
risk of PTRPA infections is associated with previous administration of
imipenem, meropenem, ciprofloxacin, vancomycin, piperacillintazobactam, and
the presence of injury on admission.
Keywords: Pseudomonas, risk factors, piperacillin-tazobactam, resistance, nosocomial infection