doiSerbia

Interferon gamma, interleukin 8 and interleukin 10 in serum of patients with the cervical infection and symptoms of the imminent preterm delivery

Bogavac Mirjana (Medicinski fakultet, Novi Sad + Klinički centar Vojvodine, Klinika za ginekologiju i akušerstvo, Novi Sad)
Brkić Snežana (Medicinski fakultet, Novi Sad + Klinički centar Vojvodine, Klinika za infektivne bolesti, Novi Sad)
Ćelić Dejan (Medicinski fakultet, Novi Sad + Klinički centar Vojvodine, Klinika za nefrologiju i kliničku imunologiju, Novi Sad)
Simin Nataša (Prirodno-matematički fakultet, Departman za hemiju, Novi Sad)
Matijašević Jovan (Medicinski fakultet, Novi Sad + Institut za plućne bolesti, Sremska Kamenica)
Ilić Tatjana (Medicinski fakultet, Univerzitet u Novom Sadu, Novi Sad + Klinika za nefrologiju i kliničku imunologiju, Klinički centar Vojvodine, Novi Sad)

Introduction. Preterm delivery (PTD), defined as a delivery between 24th and 37th completed week, increases the risk of neonatal morbidity and mortality. There is a growing body of evidence that the intrauterine infection as well as cervicovaginal bacterial infections and Chlamydia infections are possible causes of preterm delivery. Host response to cervicovaginal and/or intrauterine infections is coupled with a release of various inflammatory mediators, many of which are cytokines. Objective. The aim of the study was to find out if cervical infection influenced the serum levels of interferon-γ (IFN-γ), interleukin 8 (IL-8) and interleukin 10 (IL-10) in patients with the clinical symptoms of the imminent preterm delivery. Methods. A total of 128 pregnant women (from 24 to 30 weeks of gestation) with the clinical symptoms of the imminent preterm delivery were divided in: study group - 85 patients with the cervical infection, and control group - 43 patients without the cervical infection. The level of cytokines in the serum was measured with commercial ELISA tests. Results. No significant difference could be found in serum levels of IFN-γ (p=0.632), IL-8 (p=0.712) and IL-10 (p=0.676) between these two investigated groups. Conclusion. The results of our study suggest that there is no significant difference in serum IFN-γ, IL-8 and IL-10 concentrations between pregnant women with the symptoms of the imminent preterm delivery who had and had no cervical infection.

Keywords: interferon gamma, interleukin 8, interleukin 10, preterm delivery, bacterial infection, Candida, Chlamydia trachomatis