Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 7-8, Pages: 548-552
https://doi.org/10.2298/SARH1308548D
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Basis of bone strength vs. bone fragility: A review of determinants of age-related hip fracture risk
Đonić Danijela (Medicinski fakultet, Institut za anatomiju, Laboratorija za antropologiju, Beograd)
Milovanović Petar (Medicinski fakultet, Institut za anatomiju, Laboratorija za antropologiju, Beograd)
Đurić Marija (Medicinski fakultet, Institut za anatomiju, Laboratorija za antropologiju, Beograd)
The burden of hip fractures in elderly population has been growing worldwide.
A particular focus has been directed towards identifying persons at high risk
of fracture. However, bone mineral density (BMD), which is currently used in
clinical settings as an indicator of risk of age-related fracture, cannot
explain all fracture cases in the elderly. In fact, the risk of hip fractures
in the elderly is associated with numerous bone features that degrade bone
strength. This review focuses on complexity of bone features that could
account for increased bone fragility in advanced age. Besides a decrease in
BMD, various macroscopic and microscopic structural parameters, as well as
the material of which the bone is composed, are subject to age-related
changes. Therefore, in order to have a more thorough assessment of the
fracture risk, it is essential to provide integrative approaches that combine
BMD measure with other relevant bone features.
Keywords: bone strength, bone fragility, hip fracture, elderly, risk
Projekat Ministarstva nauke
Republike Srbije, br. 45005