Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 7-8, Pages: 511-515
https://doi.org/10.2298/SARH1308511S
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Metabolic syndrome and C-reactive protein in patients with depressive disorder on antidepressive medication
Stanojević Albina (Specijalna bolnica za psihijatrijske bolesti „Gornja Toponica“, Niš)
Popović Irena (Specijalna bolnica za psihijatrijske bolesti „Gornja Toponica“, Niš)
Nenadović Milutin (Specijalna bolnica za psihijatrijske bolesti „Laza Lazarević“, Beograd + Medicinski fakultet, Kosovska Mitrovica)
Ravanić Dragan (Medicinski fakultet, Katedra za psihijatriju, Kragujevac)
Paunović-Milosavljević Gordana (Narodna skupština Republike Srbije, Beograd)
Introduction. Recurrent depression is a psychiatric disorder of which
etiology and pathogenesis might be related to immune response. Metabolic
Syndrome (MetS) and its components are also strongly associated with elevated
inflammatory indicators, as so as the body mass index (BMI) and total
cholesterol levels. Objective. Objective of this study was to investigate if
there was any difference in C-reactive protein (CRP) levels in patients with
recurrent depressive disorder, treated with antidepressants, compared to a
healthy control group of subjects and if there was an association between
increased CRP levels and the presence of MetS in these two groups. Methods.
Sixty subjects entered the study; of these 35 patients with the diagnosis of
recurrent depressive disorder, while the healthy control group included 25
subjects. MetS was defined according to the NCEP ATP III criteria. The
cut-off point for CRP was set at >5 mg /L. Results. There was no
statistically significant difference in the prevalence of MetS and CRP values
between the studied groups. Waist circumference and total cholesterol levels
were significantly higher in the experimental group. Patients that fulfilled
the criteria for MetS showed significantly higher values of central obesity
and arterial hypertension in the experimental group as well. The elevated CRP
levels were associated with increased frequency of MetS in depressed
patients. Conclusion. Both CRP levels and metabolic risk profile screening,
according to the international criteria, may be beneficial in order to obtain
better assessment for depressive long term medicated patients.
Keywords: C-reactive protein, Metabolic Syndrome, depression, SSRI pharmacotherapy