Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 5-6, Pages: 337-343
https://doi.org/10.2298/SARH1306337M
Full text ( 1390 KB)
Significance of serum ferritin level in the prediction of delivery of low birth weight newborns for gestational age
Milašinović Ljubomir (Klinički centar Vojvodine, Klinika za ginekologiju i akušerstvo, Novi Sad)
Višnjevac Nemanja (Klinički centar Vojvodine, Klinika za ginekologiju i akušerstvo, Novi Sad)
Bogavac Mirjana (Klinički centar Vojvodine, Klinika za ginekologiju i akušerstvo, Novi Sad)
Grujić Zorica (Klinički centar Vojvodine, Klinika za ginekologiju i akušerstvo, Novi Sad)
Mladenović-Segedi Ljiljana (Klinički centar Vojvodine, Klinika za ginekologiju i akušerstvo, Novi Sad)
Paunković Jovana (Dom zdravlja Novi Sad, Služba za zdravstvenu zaštitu žena, Novi Sad)
Introduction. Intrauterine growth restriction is one of the leading causes of
prenatal morbidity and mortality. As there is no causal therapy, prediction
of intrauterine growth retardation is one of the priorities of prenatal
healthcare. Objective. The purpose of this study was to analyze blood
ferritin level, and erythrocyte, hemoglobin and hematocrit count in pregnant
women between 3032 weeks of gestation and to set apart those with a possible
development of intrauterine growth restriction. Methods. A prospective study
was conducted that included 220 healthy pregnant women between 3032
gestational weeks. The study was done at the Clinical Center of Vojvodina,
Department of Obstetrics and Gynecology Novi Sad and Clinical laboratory from
March 1, 2008 to November 30, 2009. Serum ferritin level, hemoglobin,
hematocrit and erythrocyte count were determined from blood samples of all
pregnant women. Results. After term delivery, 8.1% of pregnant women gave
birth to low birth weight babies for gestational age but without anemia. The
value of ferritin, hemoglobin, hematocrit and erythrocyte was significantly
higher in women with low birth weight babies. In mothers with low birth
weight newborns serum ferritin level was on the average for 6.4 g/l higher
than in mothers with normal weight newborns (p<0.005). Statistically, ROC
curve analysis showed that the pregnant women with the ferritin level above
13.6 µg/L, and with erythrocyte count >3.76×1012/L, hemoglobin >117 g/L and
hematocrit >32.9%, in the period of 3032 weeks of gestation, also had a
significantly higher probability of having a low birth weight newborn for
gestational age (p<0.05). Conclusion. Based on the level of ferritin and
other parameters in the period of 3032 weeks of gestation, we can predict
pregnant women in whom we can expect development of intrauterine growth
restriction.
Keywords: pregnancy, intrauterine growth restriction, serum ferritin, erythrocytes, hemoglobin, hematocrit