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Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 3-4, Pages: 262-267
https://doi.org/10.2298/SARH1304262R
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The role of regulatory T cells in the modulation of anti-tumor immune response

Radosavljević Gordana D. (Medicinski fakultet, Centar za molekulska istraživanja, Kragujevac)
Jovanović Ivan P. ORCID iD icon (Medicinski fakultet, Centar za molekulska istraživanja, Kragujevac)
Kanjevac Tatjana V. ORCID iD icon (Medicinski fakultet, Centar za molekulska istraživanja, Kragujevac)
Arsenijević Nebojša N. ORCID iD icon (Medicinski fakultet, Centar za molekulska istraživanja, Kragujevac)

It has been shown that the loss of regulatory function by deple­ + Regulatory T cells (Treg) represent a subset of CD4 T cells whose function is to suppress immune responses. Treg lymphocytes can be divided into two subsets: natural nTreg lymphocytes that are developed in the thymus and inducible iTreg lymphocytes, which originate from conventional T lymphocytes on the periphery. The majority of Treg lymphocytes express high levels of interleukin­2 (IL­2) receptor α chain (CD25) and transcription factor FoxP3 (critical for the development and suppressor activity of iTreg lymphocytes). Cancer cells can modulate anti­tumor immune response indirectly, through the activation of Treg lymphocytes. tion of tumor­induced Treg lymphocytes may enhance effectors response, resulting in tumor rejection, while the increased number of Treg lymphocytes effectively prevents tumor destruction. nTreg lymphocytes express increasingly CTLA­4 and membrane­ bound TGF­β, which inhibits cytokine production and responses of effectors lymphocytes. iTreg lymphocytes secrete immunosuppressive cytokines such as IL­10 and TGF­β. Treg lymphocytes represent one of important obstruction in anti­tumor immunity.

Keywords: regulatory T cells, tumors, anti­tumor immune response