Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 3-4, Pages: 262-267
https://doi.org/10.2298/SARH1304262R
Full text ( 1181 KB)
Cited by
The role of regulatory T cells in the modulation of anti-tumor immune response
Radosavljević Gordana D. (Medicinski fakultet, Centar za molekulska istraživanja, Kragujevac)
Jovanović Ivan P. (Medicinski fakultet, Centar za molekulska istraživanja, Kragujevac)
Kanjevac Tatjana V. (Medicinski fakultet, Centar za molekulska istraživanja, Kragujevac)
Arsenijević Nebojša N. (Medicinski fakultet, Centar za molekulska istraživanja, Kragujevac)
It has been shown that the loss of regulatory function by deple + Regulatory
T cells (Treg) represent a subset of CD4 T cells whose function is to
suppress immune responses. Treg lymphocytes can be divided into two subsets:
natural nTreg lymphocytes that are developed in the thymus and inducible
iTreg lymphocytes, which originate from conventional T lymphocytes on the
periphery. The majority of Treg lymphocytes express high levels of
interleukin2 (IL2) receptor α chain (CD25) and transcription factor FoxP3
(critical for the development and suppressor activity of iTreg lymphocytes).
Cancer cells can modulate antitumor immune response indirectly, through the
activation of Treg lymphocytes. tion of tumorinduced Treg lymphocytes may
enhance effectors response, resulting in tumor rejection, while the increased
number of Treg lymphocytes effectively prevents tumor destruction. nTreg
lymphocytes express increasingly CTLA4 and membrane bound TGFβ, which
inhibits cytokine production and responses of effectors lymphocytes. iTreg
lymphocytes secrete immunosuppressive cytokines such as IL10 and TGFβ. Treg
lymphocytes represent one of important obstruction in antitumor immunity.
Keywords: regulatory T cells, tumors, antitumor immune response