Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 3-4, Pages: 228-231
https://doi.org/10.2298/SARH1304228S
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Juvenile Sjögren’s syndrome: Case report
Sušić Gordana (Institut za reumatologiju, Beograd)
Stojanović Roksanda (Institut za reumatologiju, Beograd + Medicinski fakultet, Beograd)
Milić Vera (Institut za reumatologiju, Beograd + Medicinski fakultet, Beograd)
Boričić Ivan (Medicinski fakultet, Institut za patologiju, Beograd)
Mandić Bojan (Stomatološki fakultet, Klinika za maksilofacijalnu hirurgiju, Beograd)
Milenković Svetislav (Medicinski fakultet, Beograd + Klinički centar Srbije, Klinika za očne bolesti, Beograd)
Introduction. Sjögren’s syndrome (SS) is an autoimmune disease of unknown
etiology, clinically manifested by dry eyes (xerophthalmia) and dry mouth
(xerostomia). In childhood SS is a rare disease, clinically atypically or
asymptomatic and is often unrecognized. We report a girl with asymptomatic,
juvenile form of primary Sjögren’s syndrome (JSS). Case Outline. A
13yearold girl was initially observed for several months due to elevated
sedimentation rate (ESR 7590 mm/h) without signs of inflammation or other
symptoms and disease signs. Subjective symptoms of dryness of the eyes and
mouth were absent at the beginning. Ophthalmologic examination demonstrated
hypolacrimia although the patients had no subjective signs of xerophthalmia.
Ultrasonography (US) revealed mild enlargement and heterogeneity of large
salivary glands parenchyma. Increased rheumatoid factor (RF), anti SSA/Ro,
anti SSB/La antibodies were found in serum. Ophthalmologic examination
demonstrated decreased lacrimation. JSS was confirmed on the basis of
ophthalmologic examination, immunological tests, histological findings of
biopsy of small and US of major salivary glands. During a 12years followup
period systemic or extraglandular manifestations of JSS and other autoimmune
diseases were not observed. Conclusion. Our experience suggests that in the
differential diagnosis of unexplained elevated ESR the primary form of JSS
should be also taken into consideration. Ultrasonographic changes of major
salivary glands in the absence of symptoms of xerostomia point out that this
noninvasive method has an important role in the diagnosis and management of
patients with JSS.
Keywords: juvenile Sjögren’s syndrome, diagnostic criteria, ultrasonography, salivary glands