Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 3-4, Pages: 173-177
https://doi.org/10.2298/SARH1304173C
Full text ( 1083 KB)
Mucinous cystadenomas of the liver
Čolović Radoje (Medicinski fakultet, Beograd)
Grubor Nikica (Medicinski fakultet, Beograd + Klinički centar Srbije, Prva hirurška klinika, Beograd)
Jovanović Miodrag (Klinički centar Srbije, Prva hirurška klinika, Beograd)
Micev Marjan (Medicinski fakultet, Beograd + Klinički centar Srbije, Prva hirurška klinika, Beograd)
Čolović Nataša (Medicinski fakultet, Beograd + Klinički centar Srbije, Prva hirurška klinika, Beograd)
Perišić Mirjana (Medicinski fakultet, Beograd + Klinički centar Srbije, Klinika za gastroenterohepatologiju, Beograd)
Latinčić Stojan (Klinički centar Srbije, Prva hirurška klinika, Beograd)
Introduction. Biliary cystadenomas of the liver are rare benign tumors prone
to malignant alteration so that a total excision is recommended. Objective.
The aim of the paper is to present our experience in treatment and to
evaluate whether a simple ablation represents the appropriate treatment.
Methods. Over a 10year period 25 patients (24 women) of the average age of
58 years suffering from cystadenomas of the liver, 18 in the right, 4 in the
left and 3 in both lobes of the liver were operated. Twentythree patients
had a single lesion, while two patients had 3 and 6 lesions, respectively.
Pain was present in 20, occasional vomiting in 4, discomfort in 2 and a sense
of fullness in 2 patients. Three patients were jaundiced, 1 due to
cystadenoma of the liver, 2 due to concomitant tumors of the head of the
pancreas, while 5 patients had concomitant diseases. Results. A total
ablation was performed in 22 patients, left lateral bisegmentectomy in 1 and
partial excision in 2 patients. Six additional procedures were performed.
Five cystadenomas of the liver had „ovarian like” stroma, all in women. A
focal malignant alteration was found in 2 patients aged 66 and 79 years,
respectively. Recurrence was registered in 1 female patient in whom a partial
excision had been done. Two patients with concomitant malignancy and 1
patient who developed malignant histiocytosis six months after surgery, died
after 1, 2 and 3 years, respectively. Conclusion. Biliary cystadenomas of the
liver may be misdiagnosed as simple liver cysts, so that „frozen section”
histology is highly recommended. In most cases the tumor may be successfully
treated by ablation up to the healthy liver tissue. Major liver resections
are rarely necessary.
Keywords: liver, cystadenoma, malignant alteration, ablation, partial excision