Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 1-2, Pages: 61-65
https://doi.org/10.2298/SARH1302061D
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Ondansetron, alfentanil and nitrous oxide in the prevention of pain on injection of propofol
Drašković Biljana (Klinika za dečju hirurgiju, Institut za zdravstvenu zaštitu dece i omladine Vojvodine, Novi Sad)
Knežević Sofija (Medicinski fakultet, Novi Sad)
Radovanović Dragana (Institut za onkologiju Vojvodine, Odeljenje za anesteziju i intenzivnu terapiju, Sremska Kamenica)
Rakić Goran (Klinika za dečju hirurgiju, Institut za zdravstvenu zaštitu dece i omladine Vojvodine, Novi Sad)
Introduction. Propofol is a widely used intravenous anesthetic with a number
of advantages over intravenous anesthetics used so far. The leading side
effect is pain on injection. Objective. Aim of the study was to determine the
impact of ondansetron, nitrous oxide and alfentanil on reducing pain during
propofol application. Methods. The paper presents a prospective, randomized,
single blind study. The study included 120 patients of ASA class I and II,
who underwent elective surgery under general anesthesia using propofol for
the induction of anesthesia. The patients were divided into four equal groups
of 30 patients. The control group received a few milliliters of saline, N
group the mixture of nitric oxide and oxygen, O group ondansetron and group A
received alfentanil. In all patients, venous occlusion was performed for 60
seconds. Pain assessment was based on the criteria and the score by
McCrirrick and Hunter. Results. Pain after the application of propofol was
present in 47 (39.2%) patients. The highest frequency of pain was recorded in
the control group (18, 60%), and significantly lower (p=0.009) in the
patients who received ondansetron (8; 26.7%) and (p=0.020), alfentanil (9;
30%). The statistical analysis proved that there was a significant
relationship between the groups and the scale of pain (χ2=13.849, p=0.031).
Conclusion. Based on the results of our study we can conclude that
intravenous ondansetron and alfentanil with venous occlusion can effectively
prevent pain during IV use of propofol.
Keywords: propofol, pain, nitrous oxide, ondansetron, alfentanil