Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 1-2, Pages: 41-47
https://doi.org/10.2298/SARH1302041S
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Relationships between obesity, lipids and fasting glucose in the menopause
Simoncig-Netjasov Aleksandra (Dom zdravlja „Dr Jovan Jovanić Zmaj“, Stara Pazova)
Vujović Svetlana (Klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Beograd)
Ivović Miomira (Klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Beograd)
Tančić-Gajić Milina (Klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Beograd)
Marina Ljiljana (Klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Beograd)
Barać Marija (Klinički centar Srbije, Klinika za endokrinologiju, dijabetes i bolesti metabolizma, Beograd)
Introduction. Menopause leads to the development of central adiposity, a more
atherogenic lipid profile and increased incidence of metabolic syndrome
independent of age and other factors. Objective. The aim of the study was to
investigate the relationships between anthropometric characteristics, sex
hormones, lipids and fasting glucose in menopausal women. Methods. The study
included 87 menopausal women, who where divided into groups according to two
criteria: BMI≥26.7 kg/m2 and BMI≥25 kg/m2. Anthropometric characteristics and
blood pressure were measured. Blood was taken at 08.00 h for fasting glucose,
triglycerides, cholesterol, HDL, LDL, apolipoprotein A, apolipoprotein B,
lipoprotein(a) (Lp(a)), C-reactive protein, fibrinogen, follicle stimulating
hormone (FSH), luteinizing hormone (LH), prolactin (PRL), estradiol,
progesterone, testosterone and sex hormone binding globulin (SHBG). Results.
Significant differences between groups were found for weight, BMI, waist,
hips circumference, waist/hip ratio (WHR), systolic and diastolic blood
pressure, Lp(a), FSH, LH, PRL (for systolic blood pressure p<0.05, for the
rest p<0.01) and fasting glucose (p<0.05). In obese and overweight women with
BMI≥26.7kg/m2 significant negative correlations were found for FSH and
glucose, SHBG and LDL, SHBG and total cholesterol, SHBG and glucose, BMI and
HDL, WC and HDL. In obese and overweight women with BMI≥25kg/m2 significant
negative correlations were found for BMI and HDL, waist circumference (WC)
and HDL, WHR and HDL, FSH and glucose, SHBG and glucose; significant positive
correlations were between BMI and glucose, WC and glucose and WHR with
triglycerides. Conclusion. Gaining weight and decreased SHBG are related to
dyslipidemia and increased fasting glucose confirming increased incidence of
metabolic abnormalities in the menopause.
Keywords: obesity, lipids, glucose, menopause