Srpski arhiv za celokupno lekarstvo 2013 Volume 141, Issue 1-2, Pages: 17-21
https://doi.org/10.2298/SARH1302017G
Full text ( 150 KB)
Cited by
Prostaglandin E2 in apical tissue fluid and postoperative pain in intact and teeth with large restorations in two endodontic treatment visits
Grga Đurica (Stomatološki fakultet, Klinika za bolesti zuba, Beograd)
Dželetović Bojan (Stomatološki fakultet, Klinika za bolesti zuba, Beograd)
Damjanov Marija (Stomatološki fakultet, Klinika za bolesti zuba, Beograd)
Hajduković-Dragojlović Ljiljana (Institut za primenu nuklearne energije - INEP, Zemun)
Introduction. Acute periapical inflammation is the most common cause of
postoperative pain developing as a result of mechanical, chemical and/or
microbial injury of periapical tissue. The major inflammatory event
responsible for periapical pain is increased vasodilatation and vascular
permeability, partly caused by prostaglandin E2, with consequent edema, which
leads to the compression of nerve fibers. Objective. The aim of this study
was to determine the concentrations of prostaglandin E2 in apical tissue
fluid after endodontic treatment of intact and teeth with large restorations
and to compare it with the occurrence and intensity of postoperative pain.
Methods. Single-rooted teeth of 24 patients, selected for this study, were
distributed into two groups: intact (group 1, n=27) and asymptomatic teeth
with large restorations (group 2, n=20). Clinical examination of the involved
teeth included the electric pulp test, recording pain on percussion,
spontaneous pain, and a radiographic examination. Samples of apical tissues
fluid were obtained from root canals at two treatment visits, and
prostaglandin E2 concentrations were measured using radioimmunoassay. Pain
intensity was assessed by visual analogue scale. Results. Prostaglandin E2
concentrations at the second visit, in teeth with large restorations, was
significantly higher (36%) than at the first treatment visit (Wilcoxon signed
rank test, p<0.05). Occurrence and intensity of spontaneous pain after the
first visit were significantly higher in group 2 (p<0.05) than in group 1.
Conclusion. These results suggest that the increased prostaglandin E2
concentration, caused by endodontic treatment of teeth with large
restorations, is well correlated with the intensity of postoperative pain.
Keywords: prostaglandin E2, endodontic treatment, pain, vital teeth