Srpski arhiv za celokupno lekarstvo 2012 Volume 140, Issue 11-12, Pages: 768-771
https://doi.org/10.2298/SARH1212768S
Full text ( 178 KB)
Mystery called sarcoidosis: Forty-four years follow-up of chronic systemic disease
Škodrić-Trifunović Vesna (Medicinski fakultet, Beograd + Klinika za pulmologiju, Klinički centar Srbije, Beograd)
Vučinić Violeta (Medicinski fakultet, Beograd + Klinika za pulmologiju, Klinički centar Srbije, Beograd)
Simić-Ogrizović Sanja (Medicinski fakultet, Beograd + Klinika za nefrologiju, Klinički centar Srbije, Beograd)
Stević Ruža (Medicinski fakultet, Beograd + Centar za radiologiju i magnetnu rezonancu, Klinički centar Srbije, Beograd)
Stjepanović Mihailo (Klinika za pulmologiju, Klinički centar Srbije, Beograd)
Ilić Katarina (Farmaceutski fakultet, Katedra za farmakologiju, Beograd)
Savić Živorad (Centar za radiologiju i magnetnu rezonancu, Klinički centar Srbije, Beograd)
Introduction. This is a presentation of a 61-year-old female patient. Since
44 years have passed from the onset of her first symptoms until the final
diagnosis of sarcoidosis, this was the reason of our decision to publish the
case. Case Outline. During the follow-up period of 44 years the patient had
ocassional polymorphic complains, such as adynamia, nausea, abdominal pains,
myalgia, arthralgia, body weight loss (8-10 kg) etc. The clinical course was
predominated by splenomegaly, hepatitis and arthralgia, and later chronic
renal failure also developed. Laboratory findings showed elevated markers of
acute inflammation and autoantibodies. The patient was hospitalized in
different university internal hospitals (gastroenterology, allergology,
rheumatology, nephrology and pulmology). Liver biopsy was performed three
times, rectum and kidney biopsy once each and finally bronchoscopy and
pulmonary biopsy was done. At last, about 40 years from the onset of the
first symptoms, in 2006 the diagnosis of lung sarcoidosis was established.
Conclusion. The final diagnosis of spleen sarcoidosis was confirmed by
pathologically verified sarcoidosis of the lungs. This case is particularly
interesting because of the presence of familial sarcoidosis (the patient’s
son also had recurrent pulmonary sarcoidosis).
Keywords: sarcoidosis, liver, spleen, lung, kidney
Projekat Ministarstva
nauke Republike Srbije, br. 175046