Srpski arhiv za celokupno lekarstvo 2012 Volume 140, Issue 9-10, Pages: 600-605
https://doi.org/10.2298/SARH1210600S
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The significance of second generation cardiac troponin I in early screening of hypoxic-ischemic encephalopathy after perinatal asphyxia
Simović Aleksandra M. (Klinika za pedijatriju, Klinički centar „Kragujevac“, Kragujevac + Medicinski fakultet, Kragujevac)
Igrutinović Zoran (Klinika za pedijatriju, Klinički centar „Kragujevac“, Kragujevac + Medicinski fakultet, Kragujevac)
Obradović Slobodan (Klinika za pedijatriju, Klinički centar „Kragujevac“, Kragujevac + Medicinski fakultet, Kragujevac)
Ristić Dragana (Klinika za pedijatriju, Klinički centar „Kragujevac“, Kragujevac)
Vuletić Biljana (Klinika za pedijatriju, Klinički centar „Kragujevac“, Kragujevac + Medicinski fakultet, Kragujevac)
Radovanović Marija (Klinika za pedijatriju, Klinički centar „Kragujevac“, Kragujevac + Medicinski fakultet, Kragujevac)
Introduction. In the last few years the use of cardiac troponin I and T, as
diagnostic and prognostic factors of ischemic myocardial injury both in adult
and neonatal medicine has been of great interest. Objective. The objective of
our research was to investigate the significance of cardiac troponin I (sTnI)
as an early indicator of the presence and severity of hypoxic-ischemic
encephalopathy (HIE) in newborns. Methods. We analyzed 55 term newborns with
HIE diagnosed based on clinical findings and ultrasonographic examination of
the central nervous system. Serum concentration of sTnIultra was determined
by immunoenzyme method during the first 24-48 hours after birth, and the
obtained findings were compared with the values of identical parameter in 36
healthy term newborns. Results. During the first 24-48 hrs after birth, serum
concentration of sTnI-ultra was significantly higher (r<0.0005) in term
newborns with HIE (0.135±0.207 μg/l) and median (0.07, 0.01- 006 μg/l) in
comparison to control group (0.0183±0.026 μg/l and median 0.01 (0.01-0.01
μg/l), with the sTnI-ultra level rising proportionally to the clinical HIE
stages. The increase of sTnI-ultra of >0.12 μg/l indicated the development of
significant cerebral damage with the sensitivity of 75% and specificity of
72.2%, while the sTnI-ultra level of >0.13 μg/l was a significant mortality
predictor with sensitivity of 76.9% and specificity of 73.8%. Conclusion. The
second generation cardiac troponin I assay highly correlates with clinical
and ultrasonographic findings in neonates with HIE, so that it can be used as
a significant diagnostic and prognostic indicator of this pathological
condition.
Keywords: hypoxic-ischemic encephalopathy, troponin I, newborn, prognosis