Srpski arhiv za celokupno lekarstvo 2012 Volume 140, Issue 7-8, Pages: 462-468
https://doi.org/10.2298/SARH1208462M
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Quality of life and results of total androgen blockade alone and with radiotherapy in the treatment of nonmetastatic prostate cancer
Milovanović Lela (Odeljenje onkologije, Zdravstveni centar, Kruševac)
Milovanović Blagoje (Odeljenje ginekologije i akušerstva, Zdravstveni centar, Kruševac)
Introduction. Hormonal treatment of prostate cancer (CaP) in the form of
total androgen blockade (TAB) with or without radiotherapy is applied in
metastatic disease and in patients with nonmetastatic and localized disease
as well. Objective. The aim of the study was to compare oncological results,
residual and newly developed symptoms during treatment and the quality of
life in patients with nonmetastatic CaP treated by using Tand in a group
treated both with Tand radiotherapy (RT+TAB). Methods. Retrospective
analysis of 126 patients with nonmetastatic CaP was performed. Follow-up was
36 months. Seventynine out of 126 patients were treated with Talone and 47
with Tand radiotherapy (TAB+RT). Overall survival, metabolic syndrome
appearance and the frequency of nonmalignant complications during treatment
were analyzed. Urinary, digestive and sexual symptoms were analyzed, as well
as the overall health condition of the patients. Results. Fatal outcome
and/or disease progression occurred in 29 out of 126 patients (23%). High
risk patients were significantly more frequent in the TAB+RT group (p=0.04).
Mortality rate was not different in both groups indicating that better
results of treatment were achieved in patients treated with TAB+RT. Metabolic
syndrome appeared in 51.6% of Tpatients and in 51.1 of TAB+RT patients,
and was significantly more frequent at the end of the follow-up than at the
beginning of the treatment (p=0.003 in Tand p=0.01 in TAB+RT group).
Urinary symptoms were more frequent than digestive symptoms in both groups.
The quality of life was slightly improved after the beginning of therapy to
be followed by the tendency of gradual decrease. Conclusion. Both modalities
of treatment were efficient. Therapy TAB+RT was more efficient in high risk
patients. Metabolic syndrome was more frequent after a long-term
administration of therapy than at the beginning. The quality of life was the
most affected in sexually active patients.
Keywords: nonmetastatic prostate cancer, total androgen blockade, radiotherapy