Srpski arhiv za celokupno lekarstvo 2012 Volume 140, Issue 5-6, Pages: 278-284
https://doi.org/10.2298/SARH1206278N
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Evaluation of psycho-motor development in children with West syndrome
Nikolić Dimitrije (Univerzitetska dečja klinika, Beograd + Medicinski fakultet, Beograd)
Ivanovski Petar (Univerzitetska dečja klinika, Beograd + Medicinski fakultet, Beograd)
Bogićević Dragana (Univerzitetska dečja klinika, Beograd + Medicinski fakultet, Beograd)
Dimitrijević Nikola (Univerzitetska dečja klinika, Beograd)
Milovanović Ivan (Institut za patološku fiziologiju, Medicinski fakultet, Beograd)
Purić Selena (Univerzitetska dečja klinika, Beograd)
Delić Jovanka (Medicinski fakultet, Beograd)
Mihailović-Stanojević Nevena (Institut za medicinska istraživanja, Beograd)
Introduction. West Syndrome (WS) is age-related epileptic encephalopathy
characterised by a triad of symptoms: specific seizure type, pathognomonic
electroencephalographic (EEG) pattern - hypsarrhythmia and delay and/or
regression in psychomotor development (PMD). Aetiologically, it occurs in
three forms: symptomatic, cryptogenic and idiopathic. Objective. Estimation
of PMD in children with WS according to aetiology. Methods. The observed
group consisted of 65 children. Age range was between 6 and 30 months. The
patients were divided into three groups according to aetiology. All patients
underwent psychological examination with Brunet-Lesine test, as well as PMD
evaluation based on achieved developmental milestones for the corresponding
age. Results. Statistically significant better values in the Human
Developmental Index (HDI) had patients with idiopathic compared to other
forms of WS, at testing after 12 months (93.0±8.1 vs. 46.8±6.1 vs. 45.6±3.8),
as well as after 24 months (93.9±7.7 vs. 51.9±5.5 vs. 50.9±4.4). The best
values of HDI after 24 months had patients with improvement in PMD with the
average of 66.2±4.4, which was statistically significant compared to those
with unchanged PMD (41.5±5.3) and with further regression in PMD (28.3±4.4).
Significant correlation was obtained between PMD after 12 and 24 months
(r=0.477), as well as a considerable improvement in HDI from the 12th to 24th
month (49.4±4.0 vs. 53.7±3.9). Conclusion. The patients with idiopathic WS
accomplished the best PMD. Improvement in PMD after 12 and 24 months of
treatment was associated with improved HDI. Improvement in PMD was observed
in all patients after 2 years of follow-up.
Keywords: West syndrome, psychomotor development, psychological testing, Human Developmental Index