Srpski arhiv za celokupno lekarstvo 2012 Volume 140, Issue 3-4, Pages: 216-220
https://doi.org/10.2298/SARH1204216L
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Pendular stromal tumour of the stomach with dominant PDGFRA immunoexpression: Case report and short literature review
Latinčić Stojan (Klinika za digestivnu hirurgiju, Prva hirurška klinika, Klinički centar Srbije, Beograd)
Čolović Nataša (Klinika za hematologiju, Klinički centar Srbije, Beograd)
Micev Marjan (Služba za patohistologiju, Klinički centar Srbije, Beograd)
Čolović Radoje (Klinika za digestivnu hirurgiju, Prva hirurška klinika, Klinički centar Srbije, Beograd)
Introduction. Gastrointestinal stromal tumours are most frequent mesenchimal
tumours of the gastrointestinal tract that originate from Cajal’s
interstitial cells that are most frequently CD-117 positive. Stromal tumours
of the stomach are the most frequent mesenchimal tumours of the
gastrointestinal tract. Such tumours are usually sessile, but rarely pendular
when they can be easily removed with a limited local excision of the stomach
wall around the pedicle. Major stomach resections are rarely necessary. Case
Outline. In a 54-year-old woman with abdominal pain and fever of unknown
aetiology, a large spherical mobile and almost painless mass was found within
the upper right abdomen. US and CT showed a mainly cystic, partly solid
tumour, of 15.5×12.5 cm in diameters. Laboratory data including tumour
markers were within normal limits. At operation a mobile and free tumour of
the stomach attached to the anterior wall with a 2.5 cm pedicle was found and
easily excised. Abdominal mucosa was normal. There was no liver metastasis or
peritoneal dissemination. Hystology and imunohistochemistry showed a rare
sclerosing sincitial subtype of stromal tumour with imunophenotype
heterogenicity with a dominant PDGFRA and rare CD-117 immunoexpression. The
postoperative recovery was uneventful. The patient was symptom-free with no
sign of recurrence after a year and a half. Conclusion. A rare subtype of
histological highly malignant stromal tumour of the stomach, macroscopically
of pendular type, that was easily excised, was presented which so far showed
a favourable evolution with no signs of recurrence.
Keywords: stomach, stromal tumour, pendular type, marked PGFRA expression, mild CD-117 expression