Srpski arhiv za celokupno lekarstvo 2011 Volume 139, Issue 11-12, Pages: 718-721
https://doi.org/10.2298/SARH1112718M
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Changes in the retrobulbar arterial circulation after decrease of elevated intraocular pressure in patients with primary open angle glaucoma
Marjanović Ivan (Klinika za očne bolesti, Klinički centar Srbije, Beograd)
Šundić Ana (Klinika za neurologiju, Klinički centar Srbije, Beograd)
Mijajlović Milija (Klinika za neurologiju, Klinički centar Srbije, Beograd)
Čovičković-Šternić Nadežda (Klinika za neurologiju, Klinički centar Srbije, Beograd)
Kontić Đorđe (Klinika za očne bolesti, Klinički centar Srbije, Beograd)
Hentova-Senćanić Paraskeva (Klinika za očne bolesti, Klinički centar Srbije, Beograd)
Marković Vujica (Klinika za očne bolesti, Klinički centar Srbije, Beograd)
Božić Marija (Klinika za očne bolesti, Klinički centar Srbije, Beograd)
Knežević Miroslav (Klinika za očne bolesti, Klinički centar Srbije, Beograd)
Introduction. An altered perfusion of the optic nerve head has been proposed
as a pathogenic factor in glaucoma. Objective. To evaluate changes of
haemodynamic parameters in the retrobulbar arterial circulation after a
decrease of elevated intraocular pressure (IOP) in patients with primary open
angle glaucoma (POAG). Methods. Twenty-six patients were examined, 14 men and
12 women, 21 up to 50 years old and 5 below, all with previously diagnosed
and treated POAG, and all examined at the Eye Clinic, Clinical Centre of
Serbia. IOP was measured both with a Goldmann aplanation tonometer and
dynamic contour tonometer. Central corneal thickness was measured with
ultrasound pachymeter. Imaging of the retrobulbar arterial circulation by
colour Doppler was performed at the Neurology Clinic, Clinical Centre of
Serbia. It involved measuring of haemodynamic parameters of the ophthalmic
artery, central retinal artery, and posterior ciliary arteries. Peak systolic
velocity (PSV) and end-diastolic velocity (EDV) were measured, and resistive
index (RI) and pulsatility index (PI) were calculated. Results. Haemodynamic
arterial parameters PSV and EDV in the ophthalmic and central retinal artery
after decrease of IOP were lower, while RI and PI were higher. In the
posterior ciliary arteries PSV, EDV and PI were lower, and RI was higher.
Conclusion. Changes of the retrobulbar arterial circulation after elevated
IOP in POAG patients are important for approach and treatment, while the role
of vascular factors in the supplement of the optic disc neuroretinal rim
could be a key for progression backlash of glaucoma and the radix of
neuroprotection.
Keywords: elevated intraocular pressure, retrobulbar arterial circulation, primary open angle glaucoma