Srpski arhiv za celokupno lekarstvo 2011 Volume 139, Issue 5-6, Pages: 402-408
https://doi.org/10.2298/SARH1106402D
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Current knowledge of bacterial vaginosis
Đukić Slobodanka (Institut za mikrobiologiju i imunologiju, Medicinski fakultet, Beograd)
Opavski Nataša (Institut za mikrobiologiju i imunologiju, Medicinski fakultet, Beograd)
Mijač Vera (Institut za mikrobiologiju i imunologiju, Medicinski fakultet, Beograd)
Ranin Lazar (Institut za mikrobiologiju i imunologiju, Medicinski fakultet, Beograd)
Bacterial vaginosis, earlier termed nonspecific vaginitis (anaerobic
vaginosis) because of the absence of recognized pathogens, is most common
vaginal syndrome of women of childbearing age affecting 15-30%. This
syndrome, whose aetiology and pathogenesis remains unknown, is characterized
by significant changes in the vaginal ecosystem. These changes consist of a
decrease in the number of lactobacilli and a large increase in the number of
anaerobic organisms. The bacteria adhere to desquamated epithelial cells with
a distinctive appearance of clue cells The main complaints of women with
symptomatic bacterial vaginosis include vaginal discharge and odour. However,
a significant number of all women who have bacterial vaginosis deny symptoms.
Bacterial vaginosis is associated with a number of gynaecologic and obstetric
complications including cervicitis, cervical neoplasia, pelvic inflammatory
disease, postoperative infections, and preterm labour. The diagnosis is most
frequently made based on vaginal smear stained according to Gram (Nugent
scoring method). Metronidazole and clindamycin are the drugs of choice for
treatment of women with bacterial vaginosis. Which women should undergo
treatment? According to the prevailing attitude, it should include women with
symptoms. Symptomatic women with frequent relapses of bacterial vaginosisas,
as a rule, have poor response to the applied therapy. To achieve better
efficiency in the treatment of such women, it is necessary to have more
extensive understanding of all factors in the pathogenesis of the syndrome.
Keywords: bacterial vaginosis, anaerobes, vaginal flora
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