Srpski arhiv za celokupno lekarstvo 2011 Volume 139, Issue 5-6, Pages: 347-352
https://doi.org/10.2298/SARH1106347A
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Favourable prognostic factors in therapy related acute myeloid leukaemia
Antonijević Nebojša (Klinika za hematologiju, Klinički centar Srbije, Beograd + Medicinski fakultet, Beograd)
Suvajdžić Nada (Klinika za hematologiju, Klinički centar Srbije, Beograd + Medicinski fakultet, Beograd)
Terzić Tatjana (Institut za patologiju, Medicinski fakultet, Beograd)
Jakovljević Branko (Institut za higijenu i medicinsku ekologiju, Medicinski fakultet, Beograd)
Janković Gradimir (Klinika za hematologiju, Klinički centar Srbije, Beograd + Medicinski fakultet, Beograd)
Elezović Ivo (Klinika za hematologiju, Klinički centar Srbije, Beograd)
Milošević Rajko (Klinika za hematologiju, Klinički centar Srbije, Beograd)
Čolović Milica (Klinika za hematologiju, Klinički centar Srbije, Beograd + Medicinski fakultet, Beograd)
Introduction. Therapy related acute myeloid leukaemia (t-AML) is a distinct
clinical entity recognized by the World Health Organization classification
occurring after chemotherapy and/or radiation treatment administered for a
previous disease. T-AML is characterised by pancytopenia, three-lineage
myelodysplasia, high frequency of unfavourable cytogenetics and short
survival. Objective. The aim of this study was to analyse clinical,
cytogenetic, and cytological characteristics of t-AML and their impact on
survival. Methods. Seventeen patients with t-AML (8 male and 9 female; median
age 59 years) were identified among 730 consecutive patients with acute
myeloid leukaemia. The degree of three-lineage dysplasia as well as
haematological, cytological and cytogenetic analyses, were assessed by
standard methods. Results. The patients survived a median of 62.5 days with
the 10% probability of survival during two years. Prognostically favourable
factors were a higher percentage of dysplastic granulocytic cells, age less
than 60 years, and presence of prognostically favourable karyotype inv(16),
t(15;17), t(8;21). Conclusion. The stated prognostic factors that include
age, cytogenetics findings and granulocytic dysplasia analysis could
contribute to adequate risk stratification of t-AML, though fuller results
would require additional analyses.
Keywords: therapy related acute myeloid leukaemia, cytology, myelodysplasia, survival
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