Srpski arhiv za celokupno lekarstvo 2011 Volume 139, Issue 5-6, Pages: 322-327
https://doi.org/10.2298/SARH1106322C
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Obesity and chronic obstructive pulmonary disease
Čekerevac Ivan (Centar za plućne bolesti, Klinički centar, Kragujevac)
Lazić Zorica (Centar za plućne bolesti, Klinički centar, Kragujevac)
Introduction. Nutritional abnormalities have one of the most important
systematic effects on chronic obstructive pulmonary disease (COPD). A
relationship between COPD and obesity has been observed and recognized. In
COPD patients, beside changes in the total body weight, changes in body
composition are also possible with the loss of fat-free mass (FFM).
Objective. This study was undertaken to evaluate the impact of obesity and
the change of body composition on the pulmonary function, dyspnoea level and
the quality of life in COPD patients. Methods. Seventy-nine patients in the
stable state of COPD were evaluated. Pulmonary function and arterial blood
gas analysis were assessed. Nutritional status was analyzed according to Body
Mass Index (BMI). Body composition was evaluated by using anthropometric
measurement by fat free mass index (FFMI). Quality of life was assessed using
the St. George Respiratory Questionnaire (SGRQ). The Visual Analogue Scale
(VAS) was used to evaluate dyspnoea. Results. The highest prevalence of
obesity (50.0%) was found in patients with mild COPD, while the lowest
prevalence was detected in very severe COPD patients (10.0%). The loss of FFM
occurred in 22.2% patients with normal body weight and in 9.0% of overweight
COPD patients. The quality of life was lower in obese patients compared to
other COPD patients. A higher dyspnoea level was also present in obese
patients. The lowest airflow obstruction was in obese patients (p=0.023). We
found a significant positive correlation between forced expiratory volume in
the first second (FEV1%) and BMI (r=0.326, p=0.003), FEV1% and FFMI (r=0.321,
p=0.004). Conclusion. The highest prevalence of obesity was in patients with
mild COPD. Obese patients with COPD had the lowest level of airflow
obstruction, higher dyspnoea level and lower quality of life in comparison to
other COPD patients.
Keywords: obesity, chronic obstructive pulmonary disease, quality of life
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