Srpski arhiv za celokupno lekarstvo 2010 Volume 138, Issue 11-12, Pages: 768-776
https://doi.org/10.2298/SARH1012768S
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Anaesthesia in children with inherited neuromuscular diseases
Simić Dušica (Univerzitetska dečja klinika, Beograd)
Bogićević Dragana (Univerzitetska dečja klinika, Beograd)
Milojević Irina (Univerzitetska dečja klinika, Beograd)
Budić Ivana (Klinika za dečju hirurgiju i ortopediju, Klinički centar, Niš)
Marković Marija (Univerzitetska dečja klinika, Beograd)
Children with inherited neuromuscular diseases often require anaesthesia for
diagnostic or therapy procedures. These patients have an increased risk of
perioperative complications due to the nature of the disease and medications
administered during anaesthesia. Many anaesthetics and muscle relaxants can
aggravate the underlying disease and trigger life-threatening reactions
(cardiorespiratory complications, malignant hyperthermia). Besides, the
neuromuscular disorders are associated with atypical and undesirable
responses to drugs used during anaesthesia and the perioperative period. The
paper presents pathophysiological basis of inherited/genetic neuromuscular
diseases and specific anaesthesiological problems. The recommendations are
suggested with the aim to make the perioperative course in children optimally
safe.
Keywords: neuromuscular diseases, children, anesthesiological risks
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