Srpski arhiv za celokupno lekarstvo 2010 Volume 138, Issue 9-10, Pages: 584-589
https://doi.org/10.2298/SARH1010584M
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Relationship between sociodemographic, anthropometric and biochemical characteristics and degree of peripheral arterial disease
Maksimović Miloš
Vlajinac Hristina
Radak Đorđe
Marinković Jelena
Đurišić Nebojša
Jorga Jagoda
Introduction. Peripheral arterial disease (PAD) is a severe atherosclerotic
condition. The relationship between various risk factors and severity of PAD,
measured by Ankle Brachial Index (ABI), has been the subject of a relatively
small number of studies. Objective. The aim of the present study was to
investigate whether there was any relationship between severity of PAD,
expressed as ABI, and anthropometric, clinical and biochemical
characteristics of patients, including inflammatory markers. Methods. The
cross-sectional study, involving 388 consecutive patients with verified PAD,
was performed at the Dedinje Vascular Surgery Clinic in Belgrade. The
diagnosis of PAD was defined by Doppler sonography as ABI<0.9, and by
symptoms. Data on cardiovascular risk factors, anthropometric parameters,
clinical and biochemical characteristics were collected for all participants.
In the analysis, χ2 test, t-test and multivariate logistic regressions were
used. Results. According to the results of multivariate analysis (the model
of which included age, percentage of body fat, average value of uric acid,
high sensitivity C-reactive protein - hsCRP ≥3 mg/L, fibrinogen ≥4 g/L,
Baecke index of physical activity at work and Baecke index of leisure-time
physical activity), the patients with more severe form of peripheral arterial
disease (ABI≤0.40) had more frequently increased high sensitivity C-reactive
protein (p=0.002), lower Baecke index of physical activity at work (p=0.050)
and lower Baecke index of leisure-time physical activity (p=0.024). Average
value of body fat was significantly higher in the patients with a less severe
form of disease (p=0.006). Conclusion. According to the results obtained, the
increased values of hsCRP and physical inactivity are associated with a more
severe form of PAD (ABI≤0.40).
Keywords: peripheral arterial disease, cross-sectional study, risk factors, high sensitivity C-reactive protein
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