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Relationship between mortality of patients with atrial fibrillation and mortality of general population in Serbia

Potpara Tatjana (Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Grujić Miodrag (Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Marinković Jelena (Institut za medicinsku statistiku i informatiku, Medicinski fakultet, Beograd)
Ostojić Miodrag (Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Vujisić-Tešić Bosiljka (Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Polovina Marija (Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Mujović Nebojša (Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Kocijančić Aleksandar (Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)

Introduction. Large population-based observational trials have shown atrial fibrillation (AF) to be an independent risk factor for increased mortality. Objective. To examine all-cause mortality and cardiovascular mortality of patients with AF compared to corresponding mortality in general population of Serbia. Methods. This longitudinal observational study included patients with nonvalvular AF as the main indication for in-hospital and/or outpatient treatment at the Clinical Centre of Serbia, Belgrade, during the period 1992-2007, if the latest date of the first diagnosed AF was early January 2003, so that the total follow-up could last at least 5 years (minimum 1 year prospectively), or until death. Patients with acute causes of AF, advanced left ventricular systolic dysfunction (LVEF≤25%), preexcitation, known malignancy or any advanced chronic disease and patients with poorly documented history of previous AF were not included. To compare mortality of study population with mortality of general population, we used standardized mortality ratio (SMR) and chi-square test, p<0.05. Results. Out of 1,100 patients (389 females, 35.4%), aged 52.7±12.2 years, with total follow-up 9.94±6.05 years (prospective 5.75±4.28, retrospective 4.21±5.51), 40% had no underlying disease; others most frequently had arterial hypertension. AF was paroxysmal in 665 (60.5%), persistent in 225 (20.5%) and permanent in 210 patients (19.1%). Newly diagnosed AF was documented in 1058 patients (96.2%). Until the end of the study, 85 patients died (7.7%). Cardiovascular death was noted in 62 patients (72.9%), most frequently in form of sudden death (27/85, 31.7%), death from congestive heart failure (18/85, 21.2%) and stroke (14/85, 16.5%). Most patients (67/85, 78.8%) had AF at the time of death. SMR for all-cause mortality was 2.43 (p<0.0001) and for cardiovascular mortality 3.03 (p<0.0001). Conclusion. All-cause mortality and cardiovascular mortality of AF patients are higher than corresponding mortality in general population of Serbia, despite active treatment.

Keywords: atrial fibrillation, all-cause mortality, cardiovascular mortality