doiSerbia

Heparin-induced thrombocytopenia occurring after surgical treatment of atrial myxoma: A case report

Đunić Irena (Institut za hematologiju, Klinički centar Srbije, Beograd)
Tomin Dragica (Institut za hematologiju, Klinički centar Srbije, Beograd)
Antonijević Nebojša (Institut za kardiovaskularne bolesti, Klinički centar Srbije, Beograd)
Gradinac Siniša (Institut za kardiovaskularne bolesti 'Dedinje', Beograd)
Kovač Mirjana (Institut za transfuziju krvi Srbije, Beograd)
Vidović Ana (Institut za hematologiju, Klinički centar Srbije, Beograd)
Đurašinović Vladislava (Institut za hematologiju, Klinički centar Srbije, Beograd)
Elezović Ivo (Institut za hematologiju, Klinički centar Srbije, Beograd)

Introduction Heparin-induced thrombocytopenia (HIT) is an acquired, prothrombotic disorder, caused by antibodies to a complex of heparin and platelet factor 4 (PF4) that activates platelets, resulting in the release of procoagulant microparticles, thrombocytopenia occurrence, generation of thrombin, and frequent thromboses. Case Outline We present a case of severe HIT in a 68-year-old female, which occurred after cardiosurgery of the left atrial myxoma with the aim to point out the importance of differential diagnosis of thrombocytopenia in patients recently exposed to heparin. Platelet count dropped on the eleventh postoperative day, six days after unfractioned heparin and enoxaparine treatment, to 4×109/l. The correct diagnosis failed to be made at first. Since thrombocytopenia remained refractory to a corticosteroid treatment and platelet transfusion, the patient was hospitalized on the 13th postoperative day at the Institute of Hematology. The diagnosis of HIT was confirmed with the high-probability clinical score (4T's) and strongly positive antiheparin-PF4 (PaGIA) test as well as positive platelet aggregation test. The treatment started with a smaller therapeutic doses of danaparoid than recommended of 750 U intravenous bolus and was followed by continuous infusions of 100 U per 1 h and intravenous gammaglobulins in full dosage for four days. The platelet count started to rise on the third day and it was completely normalized on the 5th day of the therapy. Conclusion Treatment of severe HIT with small doses of danaparoid supplemented by intravenous gamma globulin was successful. Additional awareness of heparin-induced thrombocytopenia is needed, especially of HIT in differential diagnosis of thrombocytopenia in patients recently exposed to heparin.

Keywords: HIT, low platelet counts, atrial myxoma